Medically Reviewed by Brunilda Nazario, MD on January 06, 2026
What Are Biologics, and What Are They Used for?
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What Are Biologics, and What Are They Used for?

If you have Crohn’s disease, your gastroenterologist may recommend treatment with biologic medications. These medicines are made from proteins or other living components and target specific parts of your immune system.

Their goal is to lower inflammation in the gut, control flares, and help keep the disease in remission.

The following tips can help you get the most out of your biologic treatment for Crohn’s disease.

Be Consistent With Your Doses
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Be Consistent With Your Doses

If you miss a dose, biologic treatment may not work as well. To stay consistent, set reminders for each dose on your phone.

Biologic medications come in the form of shots you can give yourself at home. They can also be given through IV at specialized centers. Keeping a calendar where you write the dates of your appointments or shots can help you stay on track with your treatment.

Record Your Symptoms
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Record Your Symptoms

Keeping track of how you feel will help your doctor figure out whether the treatment is working.

Before starting treatment: Make a list of your symptoms and assign an intensity level to each one. This will help you compare them after each shot.

After starting treatment: Write down any changes in your bowel movements, skin, or breathing, as well as any new symptoms. Share this information with your doctor.

Avoid Foods That Worsen Your Symptoms
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Avoid Foods That Worsen Your Symptoms

You can improve the results of your treatment with biologics if you avoid foods that can trigger inflammation. Some common ones include:

  • Dairy products
  • High-fiber foods
  • Carbonated beverages
  • Caffeinated drinks
  • Spicy foods

Keeping a food diary can help you better track what you eat.

Consider Quitting Smoking
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Consider Quitting Smoking

If you smoke, quitting may help you get better results from your biologic treatment. Tobacco use raises your chances of Crohn’s disease flares.

Studies show that people with Crohn’s who stop smoking for more than a year tend to have a more favorable disease progression.

Talk to your primary care doctor about options that can help you quit or cut back on nicotine safely.

Protect Your Mental Health
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Protect Your Mental Health

Biologic medications can ease the physical symptoms of Crohn’s disease, but they don’t always address emotional symptoms.

People with Crohn’s have higher rates of depression than those without the disease.

Talk to your doctor if you have five or more of the following symptoms for more than two weeks:

  • Sadness or anxiety
  • Hopelessness or negative thoughts
  • Loss of interest in activities you once enjoyed
  • Low energy or fatigue
  • Trouble sleeping or sleeping too much
  • Lack of appetite or overeating
  • Irritability or restlessness
Create a Calm Space
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Create a Calm Space

Crohn’s symptom flares — even the fear that one may happen in the future — can cause stress.

The following habits can help you manage stress while receiving treatment with biologics:

  • Doing yoga
  • Meditating every day
  • Walking regularly
  • Getting enough sleep
  • Staying connected with others
  • Seeking therapy or counseling

Take a few minutes at the end of the day to step away from work or household tasks and recharge your mental energy.

Be Mindful of Infections
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Be Mindful of Infections

One possible side effect of biologic medications is a higher risk of infections. This usually does not happen because of the medication itself, but because biologics can affect how your immune system works.

There are different types of infections, including bacterial (such as tuberculosis and pneumonia), fungal (such as yeast infections), and viral (such as the flu).

Talk with your doctor if you have new or ongoing symptoms. Your doctor may decide to change your medication.

Anti-Inflammatory Diet
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Anti-Inflammatory Diet

These foods may help lower inflammation in the gut:

  • Soft fruits: bananas, raspberries, applesauce, and blended fruits
  • Cooked vegetables: squash, carrots, and green beans
  • Omega-3 fats: fatty fish (salmon, tuna), nut butters, chia seeds, and flaxseed oil or ground flaxseeds
  • Cooked starches: potatoes, corn, white rice, and oats
  • Leafy greens: boiled or blended into smoothies

Biologic therapy, along with an anti-inflammatory diet and proper hydration, plays an important role in keeping your colon healthy.

Biosimilars: A More Accessible Option
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Biosimilars: A More Accessible Option

Biologic medications work well for treating Crohn’s disease, but they can be expensive. To expand treatment options, the FDA has approved biosimilars. These medications work similarly to biologics and often cost less.

Studies show that biosimilars meet comparable standards for safety and effectiveness.

Your doctor can help you decide if a biosimilar medication is a good option for treating your Crohn’s.

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SOURCES:

Crohn’s & Colitis Foundation: “Biologics Fact Sheet,” “Mental Health and IBD: Depression and Anxiety,” “Biosimilars – Another Option for Patients with Crohn’s Disease and Ulcerative Colitis,” “What Should I Eat with IBD?”

UChicago Medicine: “Biologics and Inflammatory Bowel Disease (IBD).”

BMJ Journals: “Risks and Benefits of Biologic Therapy for Inflammatory Bowel Diseases.”

Cleveland Clinic: “Crohn’s Disease.”

Gastroenterology: “Smoking cessation and the course of Crohn's disease: An intervention study.”

Journal of Gastroenterology and Hepatology: “Caffeine and IBD Risk: A Meta-Analysis.”

JCC Journal of Crohn’s and Colitis: “P082: Spicy food is a vital trigger for relapse in patients with inflammatory bowel disease.”

International Journal of Environmental Research and Public HealthCrohn’s and Colitis: “Flare-Ups in Crohn’s Disease: Influence of Stress and the External Locus of Control.”

Mayo Clinic: “Stress relievers: Tips to tame stress.”

The American Journal of Gastroenterology: “The Impact of Early vs. Late Biologic Initiation Among Real-World Patients With Crohn’s Disease in TARGET-IBD.”

Mount Sinai: “Biologics Is an Eye-Opener for Crohn’s Disease Therapy.”

John Hopkins Arthritis Center: “Side Effects of Biologic Medications,” “Biologic Medication Infusion Therapy: What to Expect at Your Infusion Visit.”

Oxford Academics: “Opportunistic Infections Are More Prevalent in Crohn’s Disease and Ulcerative Colitis: A Large Population-Based Study.”