Jideytro (zidesamtinib) is a targeted medicine, known as a kinase inhibitor, used to treat locally advanced (has spread to nearby tissues) or metastatic (has spread to other parts of the body) ROS1-positive non-small-cell lung cancer.
Like other medicines, Jideytro may cause side effects and interact with other medicines, supplements, or alcohol.
Keep reading to learn about possible Jideytro side effects, how to manage them, and which medicines may interact with Jideytro.
This article does not include all possible side effects or interactions. Tell your health care provider about any symptoms that concern you or do not improve.
Jideytro Side Effects
Common side effects
The most common side effects reported with Jideytro include:
- Fluid retention
- Burning, numbness, or pain in your arms, hands, legs, or feet (peripheral neuropathy)
- Constipation
- Tiredness
- Shortness of breath
Serious side effects
While less common, potentially serious side effects of Jideytro include:
- Brain or central nervous system (CNS) effects
- Lung problems
- Muscle problems
- Weak bones and fractures
- Changes in your heart rhythm
- Pancreas
If you have symptoms that feel serious or life-threatening, seek medical care right away.
How to Manage Jideytro Side Effects
While not a complete guide, the following tips can help you prevent or manage some possible side effects of Jideytro.
1. Central nervous system (CNS) effects
Jideytro can affect your CNS, which includes your brain. This can sometimes be serious. About 25% of people in clinical studies had a CNS side effect, and about 2.5% of these were severe.
Possible symptoms may include:
- Dizziness or feeling like the room is spinning
- Trouble with balance, walking, or coordination
- Memory problems or trouble with thinking or speaking
- Confusion
You should not drive or do other activities that require alertness or coordination until you know how Jideytro affects you.
Tell your health care provider if you have any new symptoms mentioned above, especially if they are severe or bothersome. Your provider may adjust your treatment.
2. Fluid retention
Edema, or fluid retention, is the most common side effect of Jideytro. About 38% of the people in studies had edema.
You may notice puffiness or swelling, often in the hands, feet, ankles, or legs.
Your health care provider may recommend steps to reduce fluid buildup and, in some cases, may prescribe a water pill (diuretic). They may also recommend other things you can do at home to reduce fluid retention, such as the following:
- Raise your legs when sitting or resting.
- Avoid standing or sitting in one position for long periods.
- Wear support or compression stockings if your provider suggests.
- Limit salty foods if your health care provider advises you to do so.
- Wear loose, comfortable clothing and shoes.
Tell your health care provider if swelling is new, quickly worsening, or comes with shortness of breath, which can be a sign of a more serious problem. If swelling does not improve or becomes bothersome, your provider may adjust your treatment.
3. Numbness or tingling
Jideytro can cause peripheral neuropathy, which is a condition that can cause nerve-related symptoms that are usually felt in the hands or feet. About one-quarter of the people in studies had peripheral neuropathy. Possible symptoms include:
- Numbness or tingling
- A “pins-and-needles” feeling
- Burning or shooting pain
- Weakness or clumsiness in the hands or feet
These symptoms can affect your balance and daily activities. Here are some tips that may help:
- Take steps to prevent falls, such as keeping walkways clear and using handrails.
- Protect your hands and feet from extreme heat or cold, as numbness can make it harder to feel injury.
- Wear well-fitting, protective footwear, and check your feet regularly for cuts or sores you might not feel.
- Ask your health care provider about safe options for easing nerve pain.
Tell your health care provider if numbness or tingling is new, worsening, or getting in the way of daily tasks. If it becomes severe, your provider may pause your treatment or lower your dose.
4. Constipation
Constipation is a common side effect of Jideytro. It was noted in about 17% of the people in clinical studies.
Symptoms of constipation may include:
- Fewer bowel movements
- Hard stools
- Straining during bowel movements
Tips to help manage constipation:
- Drink plenty of fluids throughout the day.
- Moving your body can help move your bowels. Try to get more exercise, such as walking or swimming.
- Slowly add or increase high-fiber foods into your diet, such as fruits, vegetables, beans, and whole grains. Most adults should aim for 25 to 38 grams of fiber each day.
- Ask your health care provider if an over-the-counter (OTC) stool softener, laxative, or fiber supplement such as psyllium may help.
- Try to follow a regular bathroom schedule.
Tell your health care provider if constipation lasts, is painful, or comes with stomach pain, nausea, or vomiting.
5. Tiredness or fatigue
A common side effect of Jideytro is fatigue, or feeling unusually tired or weak. In clinical studies, about 16% of people reported fatigue.
These symptoms may improve after your body gets used to the medicine. To help support healthy energy, try the following:
- Get plenty of sleep and maintain a regular sleep schedule.
- Try to include nutrient-rich foods in every meal.
- Try to get some sort of physical activity regularly. Not being active can actually worsen tiredness.
- Manage stress with things such as yoga, counseling, or massage therapy.
- Plan activities during times of day when your energy levels are highest.
- Drink enough fluids and eat regular meals or snacks.
- Include light physical activity, such as walking, if your health care provider says it is safe.
Short rest periods may help, but too much inactivity can sometimes worsen fatigue.
Tell your health care provider if fatigue is severe or getting worse, as it can sometimes indicate another problem, such as anemia, that may need treatment.
Jideytro Interactions
Jideytro can interact with other medicines, supplements, or alcohol.
An interaction happens when a substance changes how a medicine works or affects the body. Some interactions may increase the risk of side effects, while others may make Jideytro less effective.
Your body breaks down (metabolizes) Jideytro mainly through a liver enzyme called CYP3A. Medicines, supplements, or foods that affect this enzyme can change the amount of Jideytro in your blood.
This is not a full list of interactions, but the following are important to note while taking Jideytro. Always share your complete medication list with your pharmacist and other health care providers.
Medicines that can increase Jideytro levels
These medicines slow down how your body clears Jideytro. This can raise Jideytro levels in your blood and increase the risk of side effects.
Examples include:
- Certain antifungal medicines, such as itraconazole, ketoconazole, and voriconazole
- Certain antibiotics, such as clarithromycin and erythromycin
- Certain HIV or hepatitis C medicines, such as those that contain ritonavir
- Certain heart or blood pressure medicines, such as diltiazem and verapamil
If you need one of these medicines, your health care provider will decide the safest option, which may include choosing a different medicine.
Medicines that can make Jideytro less effective
These medicines speed up how your body clears Jideytro. This can lower the level of Jideytro in your blood and may make it less effective.
Examples include:
- Certain seizure medicines, such as carbamazepine, phenobarbital, and phenytoin
- Rifampin, which is a medicine for tuberculosis
Do not stop or change any medicines without talking with your health care provider first.
FAQs: Jideytro Interactions
Does Jideytro interact with grapefruit?
Possibly. Grapefruit and grapefruit juice can block the CYP3A enzyme that breaks down Jideytro, which could raise the amount of Jideytro in your body. To be safe, ask your pharmacist or other health care provider whether you should avoid grapefruit and grapefruit juice while taking Jideytro.
Does Jideytro interact with alcohol?
The Jideytro labeling does not describe a specific interaction with alcohol. Even so, it is a good idea to ask your health care provider whether drinking alcohol is safe for you, especially since alcohol may add to side effects such as tiredness or dizziness.
Does Jideytro interact with any foods or supplements?
Yes. One example is St. John’s wort, an herbal supplement sometimes used for depression. It can make your body break down Jideytro more quickly than normal. This may lower the amount of Jideytro in your bloodstream, making it less effective.
Reducing Your Risk of Side Effects and Interactions
You can help lower your risk of side effects and interactions by following all instructions from your health care provider.
Here are some helpful tips:
- Take Jideytro exactly as prescribed. Do not change your dose or stop taking it unless your provider tells you to.
- Always tell your health care provider and pharmacist about all prescription drugs, OTC medicines, and any vitamins, herbs, or other supplements you use.
- Ask your health care provider before you start or stop any medicine, vitamin, or supplement.
- Keep all follow-up appointments and lab tests.
- Report any new or worsening symptoms to your health care provider.
Your health care provider can review your treatment plan and make adjustments if needed to help ensure that this medicine is safe for you.
