Jideytro (Zidesamtinib) - Uses, Side Effects, and More

What are the most common side effects of Jideytro?

The most common side effects of Jideytro are listed below. Tell your health care provider if you have any of these side effects that bother you.

• Fluid retention
• Burning, numbness, or pain in your arms, hands, legs, or feet (peripheral neuropathy)
• Constipation
• Tiredness
• Shortness of breath
• Changes in blood test results, such as increased triglycerides and decreased red or white blood cell levels

There may be other side effects of Jideytro that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Jideytro?

While less common, the most serious side effects of Jideytro are described below, along with what to do if they happen.

Severe Allergic Reactions. Jideytro may cause allergic reactions, which can be serious. Stop taking Jideytro and get help right away if you have any of the following symptoms of a serious allergic reaction.

• Breathing problems or wheezing
• Racing heart
• Fever or general ill feeling
• Swollen lymph nodes
• Swelling of the face, lips, mouth, tongue, or throat
• Trouble swallowing or throat tightness
• Itching or skin rash
• Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
• Nausea or vomiting
• Dizziness, feeling lightheaded, or fainting
• Stomach cramps
• Joint pain

Brain or Central Nervous System (CNS) Effects. Jideytro can affect your brain or central nervous system (CNS). Call your health care provider right away if you have any of the following symptoms.

• Dizziness or feeling like the room is spinning
• Trouble with balance, walking, or coordination
• Memory problems or trouble with thinking or speaking
• Confusion
• Seeing or hearing things that others do not see or hear (hallucinations)
• Anxiety, depression, unusual changes in mood or behavior, or thoughts of harming yourself
• Seizures

Lung Inflammation. Jideytro can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. Get emergency help if you have new or worsening symptoms such as trouble breathing, cough, fever, or chest pain.

Muscle Problems. Jideytro may cause muscle problems. Muscle problems may be found by an increase of a protein in your blood called creatine phosphokinase (CPK). Keep all appointments to have your blood checked. Tell your health care provider right away if you have any new or unusual muscle pain, soreness, tenderness, or weakness. 

Weak Bones. Jideytro can cause your bones to break (fracture) more easily. Tell your health care provider if you have any pain or changes that make you less able to move or walk.

Heart Rhythm Changes. Jideytro may cause a rare, dangerous heart rhythm problem called QT prolongation and torsade de pointes. Some people have a higher risk of this, including people who are older, have other people in their family who have had these conditions, have low potassium or magnesium levels, or who take medicines that can prolong the QT interval. Tell your health care provider right away if you faint or have changes in your heart rate or rhythm, such as a fast or skipping heartbeat.

Pancreas Problems. Jideytro can cause problems with your pancreas, including pancreatitis (inflammation of the pancreas). Your health care provider may check blood tests before and during treatment to look for signs of pancreas problems, even if you do not have symptoms. Contact your health care provider right away if you have any of the following symptoms.

• Severe pain in your upper stomach that may spread to your back
• Nausea or vomiting
• Fever
• Weight loss