Which Medicines Might Raise My Heart Rate?

Medically Reviewed by James Beckerman, MD, FACC on September 27, 2026

Several medications can affect the electrical signals in your heart and make your heart beat faster. (The medical term for a fast heart rate is tachycardia.)

If you have a fast heart rate because of a medication, you also may feel:

  • Lightheaded or dizzy
  • Short of breath
  • Chest pain
  • Heart palpitations

Whatever you think the reason may be, you should call 911 if you:

  • Have a hard time breathing
  • Have chest pain that lasts more than a few minutes

Many of these can cause a fast heartbeat, including inhaled corticosteroids, albuterol, inhaled long-acting beta-2 agonists, leukotriene modifiers, and oral Ciprofloxacin (Cipro, Cipro XR, Proquin XR)

Azithromycin (Zithromax) is an antibiotic that may speed up your heart rate. Other antibiotics, such as amoxicillin, ciprofloxacin, and levofloxacin, can change your heart rate, too. It’s more likely to happen if you have heart disease.

Many over-the-counter decongestants have pseudoephedrine or phenylephrine. These ingredients can cause heart palpitations or raise your blood pressure.

If your thyroid doesn’t make enough of a certain hormone (a condition called hypothyroidism), you may take a drug called levothyroxine (Levothroid, Levoxyl, Synthroid) to replace that hormone. A fast heartbeat is a possible side effect of that drug.

Certain medicines used to treat depression can raise your heart rate. They include serotonin and norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine, duloxetine, and venlafaxine, and tricyclic antidepressants such as amitriptyline, clomipramine, desipramine, and others.

Some supplements can trigger a fast or irregular heartbeat. Examples include bitter orange,  ephedra, ginseng, hawthorn, and valerian.

Talk to your doctor if you notice any changes in your heart rate. If it’s happening because of a medicine you take, your doctor can make some changes that should help:

  • Change your dose.
  • Switch you to a different medicine.
  • Change how you take your medication. For example, you may have fewer side effects if you breathe in a medication instead of taking it as a pill or liquid.

Your doctor can also tell you which over-the-counter medicines are less likely to cause heart rhythm problems.

If you have a heart problem, talk to your cardiologist (your heart doctor) before you take any prescription or over-the-counter medicines. Some medicines and supplements can cause serious complications on their own or when you take them with other medicines.

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