Lumvoa Side Effects: What to Expect and How to Manage Them

Written by Christie Denton, BCPS, PharmD
Medically Reviewed by Beth Johnston, BCPS, PharmD on August 13, 2026

Lumvoa (veligrotug-vvze) is an injectable medicine used to treat thyroid eye disease. 

Like most medicines, Lumvoa may cause side effects. Some side effects are more common than others, and some may improve as your body adjusts to treatment.

Keep reading to learn about common side effects of Lumvoa, how to prevent them, what to do if they happen, and when to tell your health care provider.

This article does not include all possible side effects of Lumvoa. Tell your health care provider if you have side effects that are ongoing or bother you, even if they are not listed.

The most common side effects reported in clinical studies include:

  • Muscle spasms
  • Headache
  • High blood sugar
  • Tiredness
  • Diarrhea
  • Ear discomfort and hearing loss

In most cases, these side effects are temporary and often improve on their own. However, contact your health care provider if you experience symptoms that feel severe or do not go away. Do not stop taking Lumvoa unless your provider recommends it.

Less common but potentially serious side effects of Lumvoa may include:

If you think you may be having a serious side effect, contact your health care provider right away. In some cases, severe symptoms may require urgent medical care. Your provider can examine your symptoms and explain what steps to take next.

Some side effects can be managed in simple ways. The sections below explain common Lumvoa side effects and what you can do to help prevent or relieve them.

1. Muscle spasms

Muscle spasms are the most common side effect of Lumvoa. In studies, 40% of people receiving Lumvoa reported muscle spasms. Muscle spasms feel like a sudden tightening of the muscle.

Muscle spasms or cramps usually stop within a few minutes and can often be managed at home by stretching, rubbing, or applying an ice pack to the affected area. 

These things may help lower your risk of muscle spasms:

  • Eating healthy and staying hydrated by drinking plenty of fluids
  • Limiting the amount of alcohol that you drink
  • Stretching regularly

Tell your health care provider if you get muscle cramps often or if they bother you.

2. Headache

Headache is a common side effect of Lumvoa. Headache occurred in 17% of people who received Lumvoa in studies. Symptoms may include mild-to-moderate head pain or pressure.

To help manage headaches:

  • Rest in a quiet, dark room if needed.
  • Drink enough fluids throughout the day.
  • Try relaxation techniques, such as deep breathing.
  • Maintain a regular sleep schedule.
  • Minimize stress.

An over-the-counter (OTC) pain reliever may help ease headache pain, but check with your health care provider or pharmacist first to make sure it is safe for you.

3. High blood sugar

High blood sugar is a common side effect of Lumvoa. In studies, high blood sugar occurred in 13% of people who received Lumvoa. 

Possible symptoms of high blood sugar include feeling thirsty, peeing more often than normal, feeling tired, or having headaches.

Hyperglycemia (high blood sugar) can usually be managed at home. If you have high blood sugar, be sure to:

  • Follow your health care provider’s instructions about testing your blood sugar. 
  • Keep a log of your blood sugar readings.
  • Inform your health care provider if you are having frequent high blood sugar readings.

4. Tiredness

Tiredness or fatigue is a common side effect of Lumvoa. In studies, tiredness was reported in 13% of people who received Lumvoa.

These symptoms may improve after your body gets used to the medicine. To help support healthy energy, try the following:

  • Get plenty of sleep and maintain a regular sleep schedule.
  • Try to include nutrient-rich foods in every meal.
  • Try to get some sort of physical activity regularly. Not being active can actually worsen tiredness.
  • Minimize stress. Consider things such as yoga, counseling, or massage therapy.
  • Maintain a regular sleep schedule.
  • Plan activities during times of day when energy levels are highest.
  • Drink enough fluids and eat regular meals or snacks.
  • Include light physical activity, such as walking, if your health care provider says it is safe.

Short rest periods may help, but too much inactivity can sometimes worsen fatigue.

5. Diarrhea

Diarrhea is a common side effect of Lumvoa. Possible symptoms include loose or watery stools, stomach cramps, and an urgent need to use the bathroom.

Mild diarrhea often improves on its own within a short time. To help manage diarrhea at home:

  • Eat bland foods, such as rice, bananas, or toast.
  • Avoid greasy, spicy, or high-fiber foods that may worsen symptoms. Avoid caffeine and alcohol.
  • Avoid fried foods, and limit dairy products such as butter and cream.
  • Drink fluids often to prevent dehydration. Opt for water, broth, or electrolyte drinks such as Gatorade or Pedialyte.
  • Ask your health care provider if an OTC antidiarrheal medicine may help.

6. Ear discomfort

Ear discomfort is a common side effect of Lumvoa. In studies, 10% of people who received Lumvoa reported feeling ear discomfort.

Possible symptoms of ear discomfort include a feeling of fullness, pressure, or blockage in the ear.

The following tips may help manage ear discomfort:

Tell your health care provider if your ear discomfort worsens, does not go away, or causes trouble hearing.

Can Lumvoa cause long-term side effects?

Yes. Lumvoa has been reported to cause hearing loss in some people. Hearing loss from Lumvoa can be permanent. Your health care provider should test your hearing before starting Lumvoa, during, and after treatment to watch for signs of hearing loss. Report any changes in hearing right away to your health care provider.

Does Lumvoa cause hair loss?

Yes. Hair loss has been reported in some people who received Lumvoa, but it is not very common, occurring in about 5% of people treated with Lumvoa. Talk to your health care provider if you have concerns.

You can lower your risk of side effects by:

  • Taking Lumvoa exactly as prescribed
  • Following any instructions about when and how to take the medicine (for example, with food or at a specific time of day)
  • Keeping track of any new or changing symptoms and sharing them with your health care provider
  • Telling your health care provider about side effects that do not improve or start to interfere with daily activities

Your health care provider can help you decide whether changes to your treatment plan are needed.

 

Add WebMD as a Preferred Source to see more of our trusted content across Google Search, AI Overviews, and AI Mode