5 mins read

Overview: Lumvoa is used to treat thyroid eye disease (TED). It is given as an infusion into a vein. Common side effects may include muscle spasms, headache, hearing loss, high blood sugar, tiredness, or diarrhea. Contact your health care provider right away if you have any trouble hearing, diarrhea, stomach pain or cramping, fever, or chills. These could be symptoms of a serious side effect. Tell your health care provider about all of your medical conditions before using Lumvoa.

Uses

What is Lumvoa used for?

Lumvoa (veligrotug-vvze) is commonly used to treat thyroid eye disease (TED).

Treating Thyroid Eye Disease With Lumvoa

Lumvoa may also be used for other conditions as determined by your health care provider.

How does Lumvoa work (mechanism of action)?

Thyroid eye disease is a rare autoimmune condition that happens when the body’s immune system mistakenly attacks tissues around the eye. This can lead to symptoms such as bulging eyes, double vision, trouble seeing, and eye pain. These symptoms may happen because of signals from insulin-like growth factor-1 (IGF-1) receptors. Lumvoa is thought to work by attaching to IGF-1 receptors and blocking these signals, which may help reduce symptoms of thyroid eye disease.

How is Lumvoa supplied (dosage forms)?

Lumvoa is available in an injectable form that is given by a health care provider.

How should I store Lumvoa?

Lumvoa is usually given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Lumvoa?

The most common side effects of Lumvoa are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Muscle spasms
  • Headache
  • Trouble hearing or hearing loss (see below)
  • High blood sugar (see below)
  • Tiredness
  • Diarrhea
  • Ear discomfort
  • Infusion reactions (see below)
  • Nausea
  • Common cold symptoms
  • Dry skin
  • High blood pressure (hypertension)

 

There may be other side effects of Lumvoa that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

 

What are the serious side effects of Lumvoa?

While less common, the most serious side effects of Lumvoa are described below, along with what to do if they happen.

Severe Allergic Reactions. Lumvoa may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infusion Reactions. Lumvoa can cause reactions that can be serious when it is given to you. Your infusion may need to be slowed or stopped if you have these reactions. Tell your health care provider right away if you have any of the following symptoms when you get your infusion or afterwards.   

  • Increased blood pressure
  • Fever or chills
  • Headache
  • Tiredness

Inflammatory Bowel Disease. Lumvoa may cause or worsen inflammatory bowel disease (IBD), which is when the intestines become inflamed. Tell your health care provider right away if you have any symptoms of IBD, including the following. 

  • Diarrhea 
  • An urgent need to poop
  • Blood in your poop
  • Stomach pain or cramping
  • Nausea or vomiting
  • Fever
  • Poor appetite
  • Tiredness 
  • Unexpected weight loss

High Blood Sugar. Lumvoa may cause high blood sugar (hyperglycemia). Talk to your health care provider about how to maintain healthy blood sugar levels. Keep all appointments with your health care provider to check your blood work. Call your health care provider if you have the following symptoms of high blood sugar.

  • Thirsty more than usual
  • Peeing more than usual
  • Increase in hunger
  • Tiredness
  • Feeling sick to your stomach
  • Confusion
  • Your breath smelling fruity

Trouble Hearing or Hearing Loss. Lumvoa may cause trouble hearing, which can sometimes be severe or include hearing loss. In some cases, hearing loss with Lumvoa can be permanent. Keep all appointments with your health care provider to check your hearing before, during, and after treatment with Lumvoa. Tell your health care provider right away if you have any trouble hearing, loss of hearing, or other changes in hearing.

Warnings & Precautions

Who should not use Lumvoa?

Allergies to Ingredients. People who are allergic to any of the following should not use Lumvoa.

  • Lumvoa 
  • Veligrotug-vvze
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Lumvoa.

 

What should I know about Lumvoa before using it?

Lumvoa is usually given by a health care provider in a hospital or clinic. It is given as an infusion into a vein (IV).

Your health care provider may have you take certain medicines before your infusion to help reduce the risk of side effects. Follow all instructions from your health care provider.

What should I tell my health care provider before using Lumvoa?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Lumvoa is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

Pregnancy. Lumvoa may cause harm to a fetus. Your health care provider will likely do a pregnancy test before starting Lumvoa. You should use effective birth control before starting Lumvoa, while using it, and for 6 months after your last dose. Tell your health care provider right away if you are pregnant, think you might be pregnant, or plan to become pregnant.

Breastfeeding. It is not known if Lumvoa passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. 

How can I get more information about Lumvoa?

For more information about Lumvoa, you can visit the drugmaker’s website at www.lumvoa.com or call them at 866-321-8736.

Interactions

Does Lumvoa interact with foods or drinks?

There are no known interactions between Lumvoa and foods or drinks.

It is unknown if drinking alcohol will affect Lumvoa.

Does Lumvoa interact with other medicines (drug interactions)?

There are no known interactions between Lumvoa and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Lumvoa?

If you or someone else has used too much Lumvoa, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Lumvoa?

Lumvoa is usually given by a health care provider in a hospital or clinic. Your health care provider will make sure you are receiving Lumvoa as scheduled. If you miss an appointment to get your Lumvoa dose, call to make another appointment as soon as possible.