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Overview: Revtorpyk is used to treat certain types of breast cancer. It works by blocking multiple proteins that cancer cells use to grow and survive. Common side effects include mouth sores, high blood sugar, nausea, rash, tiredness, and diarrhea. Contact your health care provider right away if you have severe mouth sores or a new or worsening rash. Revtorpyk is given by a health care provider as an infusion into a vein.

Uses

What is Revtorpyk used for?

Revtorpyk (gedatolisib) is commonly used to treat certain types of breast cancer.

What to Know About Revtorpyk for Breast Cancer

Revtorpyk may also be used for other conditions as determined by your health care provider.

How does Revtorpyk work (mechanism of action)?

Revtorpyk is a targeted therapy for cancer. It works by blocking multiple types of proteins that help cancer cells grow and survive. Revtorpyk can help slow tumor growth and cause cancer cells to die.

How is Revtorpyk supplied (dosage forms)?

Revtorpyk is available in an injectable form that is given by a health care provider.

How should I store Revtorpyk?

Revtorpyk is usually given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Revtorpyk?

The most common side effects of Revtorpyk are listed below. These side effects may vary depending on the other medicines used with Revtorpyk. Tell your health care provider if you have any of these side effects that bother you.

  • Mouth sores (see below)
  • High blood sugar (see below)
  • Nausea or vomiting
  • Rash (see below)
  • Changes in blood cell counts and liver function tests
  • Tiredness
  • Muscle or joint pain
  • Itchiness
  • Diarrhea 

There may be other side effects of Revtorpyk that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Revtorpyk?

While less common, the most serious side effects of Revtorpyk are described below, along with what to do if they happen.

Severe Allergic Reactions. Revtorpyk may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Mouth Sores. Revtorpyk can cause mouth sores or ulcers, which can sometimes be severe. Your health care provider may prescribe an alcohol-free mouth rinse that contains a steroid when you start Revtorpyk. Use it exactly as directed to help prevent or lessen mouth sores. Tell your health care provider if you have any of the following symptoms in your mouth.

  • Pain
  • Swelling or irritation
  • Sores or ulcers
  • Redness

High Blood Sugar. Revtorpyk may increase your blood sugar levels, which can lead to or worsen high blood sugar (hyperglycemia) or diabetes. Talk to your health care provider about how to maintain healthy blood sugar levels. Keep all appointments for blood tests before and during Revtorpyk treatment. Call your health care provider right away if you have the following symptoms of high blood sugar.

  • Peeing more than usual
  • More hungry or thirsty than usual
  • Blurred vision
  • Tiredness
  • Headache
  • Confusion
  • Unexpected weight loss

Severe Rash or Skin Reactions. Revtorpyk can cause rashes, which can sometimes be severe. It may also cause serious skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), that can lead to death if not treated. If you get a new or worsening rash, call your health care provider right away. Get emergency help if you have any of the following symptoms.

  • Painful skin that looks burned and peels off
  • Flat rash or blisters on your skin, mouth, nose, and genitals
  • Red, painful, watery eyes
  • Flu-like symptoms including fever, chills, and muscle aches

Warnings & Precautions

Who should not use Revtorpyk?

Allergies to Ingredients. People who are allergic to any of the following should not use Revtorpyk.

  • Gedatolisib
  • Revtorpyk
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Revtorpyk.

What should I know about Revtorpyk before using it?

Revtorpyk is usually given by a health care provider in a hospital or clinic as an infusion into a vein. Your health care provider will let you know how many treatments you need.

You should limit how much time you spend in sunlight while you are using Revtorpyk. If you get a new rash, tell your health care provider right away.

People who are age 65 or older may be at greater risk of some side effects from Revtorpyk. Talk to your health care provider about your risks if you are in this age group.

Revtorpyk may make it hard for you to get pregnant or get your partner pregnant. Talk to your health care provider if you have concerns about this.

What should I tell my health care provider before using Revtorpyk?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Revtorpyk is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have or have had any of the following.

Pregnancy. Revtorpyk may cause harm to a fetus. If you can get pregnant, your health care provider will give you a pregnancy test to make sure you are not pregnant before starting treatment. If you are able to get pregnant, you should use effective birth control while using Revtorpyk and for 2 weeks after your last dose. If you can get a partner pregnant, you should use effective birth control (such as condoms) while using Revtorpyk and for 2 weeks after your last dose. Talk with your health care provider about effective birth control options. Tell your health care provider right away if you are pregnant, think you are pregnant, or plan to become pregnant.

Breastfeeding. It is not known if Revtorpyk passes into breast milk. You should not breastfeed while using Revtorpyk and for 2 weeks after your last dose. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Revtorpyk?

For more information about Revtorpyk, you can visit the drugmaker’s website at revtorpyk.com or call them at 877-423-5284.

Interactions

Does Revtorpyk interact with foods or drinks?

There are no known interactions between Revtorpyk and foods.

It is best to avoid drinks and mouthwash products that contain alcohol while using Revtorpyk. Alcohol can worsen mouth sores. See the Side Effects section for more details.

It is unknown if drinking alcohol will affect Revtorpyk, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.

Does Revtorpyk interact with other medicines (drug interactions)?

There are no known interactions between Revtorpyk and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

This may not be a complete list of medicines that can interact with Revtorpyk. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Revtorpyk?

If you or someone else has used too much Revtorpyk, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Revtorpyk?

If you miss an appointment to get your Revtorpyk dose, call to make another appointment as soon as possible.