Overview: Capsicum is available as a supplement and in homeopathic products. People use capsicum for many reasons, but its benefits are not well defined. Supplements and homeopathic capsicum are not the same as over-the-counter (OTC) and prescription capsaicin products. Side effects from capsicum are not well studied, but the most likely side effects are stomach-related, such as acid reflux, nausea, gas, and indigestion. Tell your health care provider about all of your health conditions and medicines you take before taking capsicum.
Uses
What is capsicum used for?
Capsicum (Capsicum annuum, Capsicum chinense, Capsicum frutescens, and others) may be used for many reasons. However, the benefits are not well defined. Common reasons that people may take capsicum include the following.
- Weight management
- Digestive health
- Heart health
- Blood sugar management
- Energy
Note: Capsicum is available as a dietary supplement. It is also found in certain foods or drinks. It is generally recognized as safe (GRAS) by the FDA for use in foods. Learn more about GRAS status here. The FDA has not reviewed capsicum dietary supplements for safety and effectiveness. Learn more about dietary supplements here.
How does capsicum work (mechanism of action)?
Capsicum is the common name for the peppers that grow from different species of plants (such as Capsicum chinense, Capsicum annuum, Capsicum frutescens). Common names for capsicum include cayenne pepper, red pepper, chili pepper, hot pepper, and paprika. Capsicum belongs to the Solanaceae (nightshade) family, which also includes tomatoes, potatoes, and eggplant.
Capsicum supplements are produced from these fruits and are available in oral forms such as capsules, tablets, and liquid extracts. Some capsicum products are homeopathic, meaning they are very dilute and contain only very small amounts of capsicum. Sometimes, these amounts are so small that there may not be any capsicum in the product at all.
These peppers contain a natural compound called capsaicin, which is the substance that gives chili peppers their spicy heat. Capsaicin is available in some over-the-counter (OTC) topical products and in at least one prescription medicine. These OTC and prescription medicines are not the same as capsicum supplements, which are usually taken by mouth.
The active components of capsicum are capsaicinoids, a group of compounds sometimes referred to as alkaloids. The two main capsaicinoids are capsaicin and dihydrocapsaicin. Other capsaicinoids include nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin. Capsicum fruits also contain carotenoids (capsanthin, capsorubin, beta-carotene, lutein, zeaxanthin), fats, proteins, and vitamins A and C, which contribute to their antioxidant properties. Capsaicinoid content varies considerably by species and variety. C. annuum, C. frutescens, and C. chinense are all different, but C. chinense varieties (such as habanero and ghost pepper) seem to have higher capsaicinoid concentrations than standard cayenne. This higher content may increase both effects and stomach-related side effects. See the Side Effects section for more details.
Though there is evidence to support the use of OTC and prescription capsaicin products, that is not the case with capsicum supplements or homeopathic products. Almost all of the information about using capsicum comes from laboratory studies and animal data. There is not enough information on use in humans to fully understand whether or how capsicum is helpful for these uses. So, the benefits are not well defined.
Herbal products, such as capsicum, naturally contain many different chemicals. The amounts of each chemical in a specific capsicum product may vary. Some, none, or all of these chemicals may have effects on the body. These effects may change depending on how much of each chemical is found in the product you are using.
How should I store capsicum?
You should store capsicum according to the product label. Most dietary supplements should be kept in a cool, dry location that is out of the reach of children and pets and not in direct sunlight.
Side Effects
What are the most common side effects of capsicum?
The most common side effects of capsicum are listed below. These side effects may vary depending on the dose you are taking or the specific product you are using. Tell your health care provider if you have any of these side effects that bother you.
- Stomach irritation (see below)
- Upset stomach, heartburn, or acid reflux
- Nausea or diarrhea
- Gas
- Sweating or flushing (warmth or redness of the skin)
- Runny nose
- Burning sensation in the mouth or throat
There may be other side effects of capsicum that are not listed here. Contact your health care provider if you think you are having a side effect of a supplement. In the U.S., you can report side effects to the FDA at www.safetyreporting.hhs.gov or by calling 888-SAFEFOOD (888-723-3366). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of capsicum?
While less common, the most serious side effects of capsicum are described below, along with what to do if they happen.
Severe Allergic Reactions. Capsicum may cause allergic reactions, which can be serious. Stop using capsicum and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Stomach Irritation. Capsicum, especially in high doses, may cause or worsen gastrointestinal (GI) tract irritation. Tell your health care provider if you have digestive problems, a sensitive stomach, or problems with stomach irritation. Contact your health care provider if you have any of the following.
- Severe stomach pain
- Vomiting, especially if it is bloody
- Blood in your stool (poop)
Warnings & Precautions
Who should not use capsicum?
Allergies to Ingredients. People who are allergic to any of the following should not use capsicum.
- Capsicum
- Capsicum annuum
- Capsicum chinense
- Capsicum frutescens
- Cayenne
- Chili pepper
- Hot pepper
- Paprika
- Red pepper
- Any of the ingredients in the specific product
Your pharmacist can tell you all of the ingredients in the specific capsicum products they stock.
What should I know about capsicum before using it?
Capsicum is available as a dietary supplement and in homeopathic products. These cannot be marketed to treat or cure a disease.
Read and follow the directions on the specific product you are using, or use it as recommended by your health care provider.
Keep capsicum out of the reach of children.
Some capsicum products are homeopathic, meaning they contain only very small amounts of capsicum. These small amounts are unlikely to be poisonous or cause serious side effects. But some homeopathic products have been found to contain larger amounts than listed on the label and can cause side effects. The FDA has not tested capsicum products to confirm that they contain the ingredients or amounts stated on their labels. Learn more about the risks of homeopathic products here.
Capsicum products are not the same as OTC topical capsaicin pain relievers, such as creams, gels, or patches, or prescription capsaicin patches. Do not substitute one for another.
Herbal products, such as capsicum, naturally contain many different chemicals. The amount of each chemical in a specific capsicum product can change for many reasons, including the area where the plant was grown, the weather during growth, the time of year it was harvested, and the way the plant was processed after it was harvested. If you switch to a new bottle or a different brand, you may not have the same effects or side effects because of this variability. Talk to your health care provider if you have questions or concerns.
Capsicum supplements can be made from different species of the plant, including Capsicum annuum (cayenne), Capsicum frutescens, and Capsicum chinense (habanero, ghost pepper). These species have different capsaicinoid profiles, with C. chinense varieties typically being considerably more pungent. A supplement derived from C. chinense at the same labeled dose as a cayenne supplement may deliver a much higher capsaicinoid load. Capsicum supplements come in many forms, including capsules, tablets, and liquid extracts. Read the product label to understand which species and form was used.
The FDA has not tested capsicum products to confirm that they contain the ingredients stated on their labels. Some dietary supplements have been tested by third-party organizations to confirm that they contain the ingredients listed on their labels and do not contain any harmful chemicals. Learn more about how to choose a safe dietary supplement product here.
What should I tell my health care provider before using capsicum?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if capsicum is right for you.
Current and Past Health Conditions. Tell your health care provider if you have any of the following.
- Stomach problems, including acid reflux or GERD, stomach tears or ulcers, or irritable bowel syndrome (IBS), ulcerative colitis, or Crohn’s disease
- Diabetes
- High blood pressure
- Heart disease
Other Medicines and Supplements. Capsicum may interact with other medicines and supplements. Before taking capsicum, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how capsicum could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.
Breastfeeding. It is not clear whether capsaicin from capsicum supplements passes into breast milk. Limited evidence suggests possible effects on breastfed infants after eating foods containing capsicum, but more data is needed to confirm whether taking capsicum supplements does. Tell your health care provider if you are breastfeeding or plan to breastfeed.
Interactions
Does capsicum interact with foods or drinks?
There are no known interactions between capsicum and foods or drinks. However, if you have stomach irritation with capsicum, you can try taking it with food to see if that helps.
It is unknown if drinking alcohol will affect capsicum. Combining alcohol with capsicum may increase stomach-related side effects, as both may cause these effects.
Does capsicum interact with medicines (drug interactions)?
Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
The interactions listed below are based on laboratory and animal studies. They have not been confirmed in humans. However, as a precaution, discuss these medicines with your health care provider before using capsicum.
- An angiotensin-converting enzyme (ACE) inhibitor, such as enalapril or lisinopril, which is a medicine for high blood pressure, heart failure, and certain kidney problems
- A nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which is in many prescription and OTC products for pain, swelling, and fever
- A blood thinner, which is a medicine used to treat or prevent blood clots
- An antiplatelet medicine, such as aspirin/dipyridamole, cilostazol, clopidogrel (Plavix), or ticagrelor (Brilinta), which is a medicine used to prevent blood clots
This may not be a complete list of medicines that can interact with capsicum. The interactions between capsicum and medicines are not fully understood. As with most dietary supplements, the research on drug interactions with capsicum is incomplete. Always check with your health care provider before taking capsicum with any medicines.
Overdose/Missed Dose
What should I do if I accidentally use too much capsicum?
If you or someone else has used too much capsicum, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
Read the product label closely and speak to a health care provider about how to use capsicum safely. Do not take double or extra doses, even if you miss a dose.
Add WebMD as a Preferred Source to see more of our trusted content across Google Search, AI Overviews, and AI Mode

