Overview: Blue-green algae are a group of organisms called cyanobacteria. The most common types in over-the-counter (OTC) dietary supplements are spirulina and Aphanizomenon flos-aquae (AFA). People take blue-green algae for many reasons, such as general nutrition, high cholesterol, high blood pressure, blood sugar support, allergies, and immune support, although the benefits are not well defined. Common side effects include nausea, diarrhea, and stomach pain. Blue-green algae products, especially those with AFA, may contain harmful toxins. Check with your health care provider before using blue-green algae, especially if you have any health conditions or take any medicines.
Uses
What is blue-green algae used for?
Blue-green algae are used for many reasons, although the benefits are not well defined. Some common reasons for taking blue-green algae include the following.
- High cholesterol or high triglycerides
- High blood pressure
- Diabetes
- Immune support
- Allergies
- Weight management
- General nutrition or protein supplement
- Cancer
Note: The FDA has not reviewed blue-green algae for safety and effectiveness. Learn more about dietary supplements here.
How does blue-green algae work (mechanism of action)?
Blue-green algae are microscopic organisms called cyanobacteria. Despite the name “algae,” they are technically bacteria that can produce energy from sunlight, similar to plants. The most common types used in dietary supplements are spirulina (also known as Arthrospira platensis, Arthrospira maxima, or Spirulina fusiformis) and Aphanizomenon flos-aquae (AFA). Spirulina is typically grown in controlled environments, while AFA is usually harvested from natural bodies of water.
Lab studies show that blue-green algae reduce inflammation by affecting certain chemical pathways in the body. Blue-green algae may also have antioxidant effects, meaning they may help protect cells from damage. Some research suggests that blue-green algae may affect blood sugar, blood pressure, and cholesterol levels, but the actual effects in people are not well understood.
Blue-green algae supplements naturally contain many different chemicals. Blue-green algae are also naturally rich in nutrients, especially protein, B vitamins, minerals, essential fatty acids, and pigments. The main active compounds thought to be responsible for the effects of blue-green algae include the following.
- Beta-carotene and other carotenoids, which act as antioxidants
- Gamma-linolenic acid (GLA), an omega-6 fatty acid
- Polysaccharides, which may support immune function
- Phycocyanin, a blue pigment that may have antioxidant and anti-inflammatory properties (phycocyanin from spirulina is also used as a food coloring in certain foods and drinks)
The amount of each chemical in a specific product may vary from product to product. Some, none, or all of these chemicals may have effects on the body. These effects may change depending on how much of each chemical is found in the product you are using.
How should I store blue-green algae?
You should store blue-green algae according to the product label. Most dietary supplements should be kept in a cool, dry location that is out of the reach of children and pets and not in direct sunlight.
Side Effects
What are the most common side effects of blue-green algae?
The most common side effects of blue-green algae are listed below. These side effects may vary depending on the dose you are taking or the specific product you are using. Tell your health care provider if you have any of these side effects that bother you.
- Nausea
- Diarrhea
- Stomach pain
- Skin rash
- Trouble sleeping
There may be other side effects of blue-green algae that are not listed here. Contact your health care provider if you think you are having a side effect of a supplement. In the U.S., you can report side effects to the FDA at www.safetyreporting.hhs.gov or by calling 888-SAFEFOOD (888-723-3366). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of blue-green algae?
While less common, the most serious side effects of blue-green algae are described below, along with what to do if they happen.
Severe Allergic Reactions. Blue-green algae may cause allergic reactions, which can be serious. Stop taking blue-green algae and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Toxin Exposure and Liver Damage. Some blue-green algae products, especially those containing Aphanizomenon flos-aquae (AFA), may be contaminated with toxins called microcystins. Consuming contaminated blue-green algae products may cause headache, sore throat, cough, mouth blisters, pneumonia, and digestive issues, such as vomiting. These toxins can also damage the liver or other organs. Call your health care provider right away if you have any of the following symptoms of liver damage.
- Nausea or vomiting
- Stomach or belly pain
- Fever
- Weakness or unusual tiredness
- Itching
- Loss of appetite
- Light-colored poop
- Dark-colored urine (pee)
- Your skin or the whites of your eyes turning yellowish (also called jaundice)
Warnings & Precautions
Who should not use blue-green algae?
Allergies to Ingredients. People who are allergic to any of the following should not take blue-green algae.
- Aphanizomenon flos-aquae (AFA)
- Blue-green algae
- Spirulina (Arthrospira platensis or Arthrospira maxima)
- Any of the ingredients in the specific product
Your pharmacist can tell you all of the ingredients in the specific blue-green algae products they stock.
What should I know about blue-green algae before using it?
Blue-green algae are used as dietary supplements. They cannot be marketed to treat or cure a disease.
Read and follow the directions on the specific product you are taking, or take it as recommended by your health care provider.
Keep blue-green algae out of the reach of children.
Blue-green algae supplements can vary in their nutritional content and safety depending on the species used, where it was grown, and how it was processed. If you switch to a new bottle or a different brand, you may not have the same effects or side effects because of this variability. Talk to your health care provider if you have questions or concerns.
Blue-green algae products, especially those made from AFA, may be contaminated with harmful substances called cyanotoxins, including microcystins. See the Side Effects section for more details. Blue-green algae can absorb heavy metals from the water in which they grow. While studies have found that heavy metal levels in commercially available blue-green algae products generally do not exceed safe limits, the levels can vary between products and batches.
The FDA has not tested blue-green algae products to confirm that they contain the ingredients stated on their labels. Some dietary supplements have been tested by third-party organizations to confirm that they contain the ingredients listed on their labels and do not contain any harmful chemicals. Learn more about how to choose a safe dietary supplement product here.
What should I tell my health care provider before using blue-green algae?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if blue-green algae is right for you.
In particular, make sure that you discuss any of the following.
Other Medicines and Supplements. Blue-green algae may interact with other supplements and medicines. Before taking blue-green algae, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Autoimmune Disease. Before taking blue-green algae, tell your health care provider if you have an autoimmune condition, such as lupus, rheumatoid arthritis, or multiple sclerosis. Blue-green algae may stimulate the immune system, which could lead to a symptom flare or worsen your condition.
Phenylketonuria (PKU). Blue-green algae are high in protein. People with PKU should be aware that blue-green algae contain phenylalanine (Phe), which is found in protein. If you have PKU, check with your health care provider before use.
Other Current and Past Health Conditions. Tell your health care provider if you have any of the following.
- Bleeding disorders
- Underactive thyroid or other thyroid problems
- Kidney problems
- Liver problems
Pregnancy. It is not known if or how blue-green algae could affect pregnancy or harm a fetus. There is also a risk that blue-green algae products may contain contaminants such as microcystins, which could be harmful. Tell your health care provider if you are pregnant or plan to become pregnant.
Breastfeeding. It is not known if blue-green algae pass into breast milk. There is also a risk that blue-green algae products may contain contaminants that could be harmful. Tell your health care provider if you are breastfeeding or plan to breastfeed.
Interactions
Does blue-green algae interact with foods or drinks?
There are no known interactions between blue-green algae and foods or drinks.
It is unknown if drinking alcohol will affect blue-green algae.
Does blue-green algae interact with medicines (drug interactions)?
Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking blue-green algae.
- A blood thinner, which is a medicine used to treat or prevent blood clots
- A medicine for diabetes
- A medicine that suppresses your immune system
The interactions between blue-green algae and medicines are not fully understood. As with most dietary supplements, the research on drug interactions with blue-green algae is incomplete. Always check with your health care provider before taking blue-green algae with any medicines.
Overdose/Missed Dose
What should I do if I accidentally use too much blue-green algae?
If you or someone else has used too much blue-green algae, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
Blue-green algae come in a range of forms, such as tablets, capsules, and powders. Read the product label closely, and speak to a health care provider about how to use blue-green algae safely. Do not take double or extra doses, even if you miss a dose.
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