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Overview: Yartemlea is used to treat a life-threatening condition that can happen after a stem cell transplant. This condition affects small blood vessels and can cause organ damage. Yartemlea works by calming part of the immune system to help prevent damage to small blood vessels. The most common side effect is infections, including serious infections. Tell your health care provider right away if you have a fever, cough, or other symptoms of a possible infection. Yartemea is usually given by a health care provider in a hospital.

Uses

What is Yartemlea used for?

Yartemlea (narsoplimab-wuug) is commonly used to treat hematopoietic stem cell transplant-associated thrombotic microangiopathy (TA-TMA).

TA-TMA is a serious condition that can happen after a hematopoietic stem cell transplant (sometimes called a bone marrow transplant). TA-TMA occurs when small blood clots form in blood vessels, which can damage your kidneys and may lead to death.

What to Know About Yartemlea for Transplant-Associated Thrombotic Microangiopathy

Yartemlea may also be used for other conditions as determined by your health care provider.

How does Yartemlea work (mechanism of action)?

Yartemlea works by blocking a key enzyme (MASP-2) in the lectin pathway of the immune system. Blocking this enzyme is thought to help prevent immune-related damage to the lining of small blood vessels and reduce small blood clots from forming. Yartemlea may reduce the risk of organ damage and death from TA-TMA.

How is Yartemlea supplied (dosage forms)?

Yartemea is available in an injectable form that is given by a health care provider.

How should I store Yartemlea?

Yartemea is usually given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Yartemlea?

The most common side effects of Yartemlea are listed below. These effects may also be related to the condition being treated. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of Yartemlea that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Yartemlea?

While less common, the most serious side effects of Yartemlea are described below, along with what to do if they happen.

Severe Allergic Reactions. Yartemlea may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infections. Yartemlea can increase your risk of infections, including serious infections. In some cases, infections can lead to sepsis, which is when your body has a severe response to an infection. Tell your health care provider right away if you have an infection or any of the following symptoms.

  • Burning or stinging when you pee 
  • Coughing, or coughing up blood
  • Fever, sweats, chills, or muscle aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Weight loss

Warnings & Precautions

Who should not use Yartemlea?

Allergies to Ingredients. People who are allergic to any of the following should not use Yartemlea.

  • Narsoplimab
  • Yartemlea
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Yartemlea.

What should I know about Yartemlea before using it?

Yartemea is usually given by a health care provider in a hospital. It is given as an infusion into your vein.

Tell your health care provider right away if you have an infection or feel like you are getting sick before or after getting this medicine. Symptoms of a possible infection may include pain or burning when you pee, cough, shortness of breath, sore throat, or fever.

What should I tell my health care provider before using Yartemlea?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Yartemlea is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Yartemlea could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Yartemlea passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Yartemlea?

For more information about Yartemlea, you can visit the drugmaker’s website at www.yartemlea.com or call them at 844-927-8361.

Interactions

Does Yartemlea interact with foods or drinks?

There are no known interactions between Yartemlea and foods or drinks.

It is unknown if drinking alcohol will affect Yartemlea. 

Does Yartemlea interact with other medicines (drug interactions)?

Yartemlea may interact with certain medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Yartemlea?

If you or someone else has used too much Yartemlea, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Yartemlea?

Yartemlea is usually given by a health care provider in a hospital. Your health care provider will make sure you are receiving Yartemlea as scheduled.

If you miss an appointment to get your Yartemlea dose, contact your health care provider as soon as possible.