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Overview: Vybrique is an oral film that dissolves on your tongue. It is used to treat erectile dysfunction, or trouble getting or keeping an erection.. Common side effects include headache, flushing, upset stomach, stuffy or runny nose, and dizziness. Serious side effects are less common, but may include low blood pressure, vision problems, hearing problems, and long or painful erections. Tell your health care provider right away if you have trouble seeing or hearing things, feel unusually weak or tired, or an erection that lasts longer than 4 hours, is painful, or is unrelated to sexual stimulation. Before taking Vybrique, make sure to tell your health care provider about any health conditions you have or medicines you are taking.

Uses

What is Vybrique used for?

Vybrique (sildenafil) is commonly used for erectile dysfunction, a condition where you have trouble getting or keeping an erection. 

Vybrique may also be used for other conditions as determined by your health care provider.

How does Vybrique work (mechanism of action)?

Vybrique works by blocking an enzyme in the body called PDE5. Blocking this enzyme helps certain blood vessels to relax, which increases blood flow. It specifically increases blood flow to the penis when aroused. This makes it easier to get and keep an erection.

How is Vybrique supplied (dosage forms)?

Brands and other names

  • Vybrique

Dosage forms and strengths

  • 25 mg, 50 mg, 75 mg, 100 mg oral film

How should I store Vybrique?

Vybrique should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Keep Vybrique inside the foil pouch until you are ready to use it.

Side Effects

What are the most common side effects of Vybrique?

The most common side effects of Vybrique are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Headache
  • Flushing
  • Upset stomach
  • Vision changes (see below)
  • Stuffy or runny nose
  • Back or muscle pain
  • Nausea
  • Dizziness
  • Rash

There may be other side effects of Vybrique that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Vybrique?

While less common, the most serious side effects of Vybrique are described below, along with what to do if they happen.

Severe Allergic Reactions. Vybrique may cause allergic reactions, which can be serious. Stop taking Vybrique and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Painful, Prolonged Erection (Priapism). Vybrique may cause an unwanted erection that is persistent, painful, and that may occur without sexual arousal. Permanent damage to the penis may occur if priapism is not treated quickly. Stop taking Vybrique and get emergency help if you have any of the following symptoms of priapism. 

  • Erection lasting for more than 4 hours 
  • Erection that is unrelated to sexual stimulation
  • Painful or tender penis

Vision Changes. Vybrique can cause mild, temporary vision changes such as trouble telling the difference between green and blue, blurry vision, or sensitivity to light. Though rare, some people have reported permanent vision loss. Your risk may be higher if you have had certain eye problems in the past. Stop taking Vybrique and get help right away if you have sudden vision loss in one or both eyes.

Hearing Loss. Vybrique may be associated with hearing loss, which is also called ototoxicity. This may happen with other symptoms, such as dizziness and ringing in the ears. Stop taking Vybrique and tell your health care provider right away if you have hearing loss or suddenly have trouble hearing as well as you normally do.

Low Blood Pressure (Hypotension). Vybrique may cause low blood pressure. You may be at higher risk if you have certain health conditions or take certain other medicines. If you feel faint or dizzy, lie down. Tell your health care provider right away if you have any of the following symptoms of low blood pressure.

  • Dizziness, feeling lightheaded, or fainting
  • Confusion
  • Feeling weak or tired

Warnings & Precautions

Who should not use Vybrique?

Allergies to Ingredients. People who are allergic to any of the following should not take Vybrique.

  • Sildenafil
  • Vybrique
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Vybrique.

Drug Interactions. Vybrique should not be taken while you are using certain other medicines. Before taking Vybrique, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Vybrique before using it?

Do not take Vybrique unless it has been prescribed to you by a health care provider. Take it as prescribed. Read and follow the “Instructions for Use” that come with your medicine. 

Do not share Vybrique with other people, even if they have the same condition as you. It may harm them.

Keep Vybrique out of the reach of children.

You should take Vybrique about 1 hour before sexual activity, but it can be taken anywhere between 30 minutes and 4 hours before sex. 

You should not cut or chew Vybrique. The film should be placed on your tongue and allowed to dissolve. It can then be swallowed with saliva (spit). You do not need to drink water or other liquids after taking it. Ask your pharmacist if you have any questions about how to take it. 

Sexual activity can put extra strain on your heart, which may be unsafe for people with certain health problems, such as a recent heart attack. Talk to your health care provider to see if your heart is strong enough for sex. If you feel chest pain, dizziness, or nausea during sex, stop and contact your health care provider right away. If you need emergency care for a heart problem, it is important that you tell your health care provider when you last took Vybrique.

Vybrique does not protect against sexually transmitted infections, including HIV.

Vybrique belongs to a group of medicines, known as phosphodiesterase-5 (PDE5) inhibitors, which are used to treat erectile dysfunction or pulmonary arterial hypertension. You should not take more than one PDE5 inhibitor medicine. Medicines in this group include avanafil (Stendra), sildenafil (Revatio, Viagra, and others), tadalafil (Cialis and others), and vardenafil (Levitra, Staxyn).

What should I tell my health care provider before using Vybrique?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Vybrique is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

Pregnancy. People who can become pregnant are not usually prescribed Vybrique. 

Breastfeeding. People who can breastfeed are not usually prescribed Vybrique. 

How can I get more information about Vybrique?

For more information about Vybrique, you can call them at 800-587-3513.

Interactions

Does Vybrique interact with foods or drinks?

You can take Vybrique with or without food. But, it may take longer for Vybrique to work if you take it with a high-fat meal.

Your health care provider may recommend limiting or avoiding grapefruit while taking Vybrique. Grapefruit or grapefruit juice can raise Vybrique levels in your body, which can increase the risk of side effects.

The risk of dizziness may be increased if you drink alcohol while taking Vybrique.

Does Vybrique interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Vybrique.

  • A nitrate, such as nitroglycerin (Nitro-Dur, NitroMist, Nitrostat, and others), isosorbide dinitrate (Isordil), or isosorbide mononitrate, which is a medicine used to prevent or treat short-lasting chest pain caused by a type of heart disease, or a street drug, such as amyl nitrite (“poppers”)
  • A guanylate cyclase stimulator, such as riociguat (Adempas), which is a medicine used for high blood pressure in the lungs (pulmonary arterial hypertension), or vericiguat (Verquvo), which is a medicine used for a type of heart failure
  • An alpha-blocker, such as alfuzosin, doxazosin, prazosin, or terazosin, which is a medicine that may be used for high blood pressure and/or trouble peeing due to an enlarged prostate
  • A calcium channel blocker, such as amlodipine (Katerzia, Norliqva), which is a medicine used for high blood pressure or other conditions
  • A medicine for high blood pressure
  • Bosentan (Tracleer), which is a medicine used for pulmonary arterial hypertension
  • A protease inhibitor, such as ritonavir (Norvir), which is a medicine commonly used to treat HIV
  • A medicine used for fungal infections, such as itraconazole (Sporanox, Tolsura) or ketoconazole
  • Erythromycin (Ery-Tab and others), which is a medicine used for bacterial infections 
  • Any other medicine used for erectile dysfunction or pulmonary arterial hypertension

Some other medicines may alter the blood levels of Vybrique. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Vybrique. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Vybrique?

If you or someone else has used too much Vybrique, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Vybrique?

Vybrique is meant to be taken only when needed. It should be taken no more than once per day. Take it as your health care provider recommends. Do not take double or extra doses.