Reviews Overview: Tryngolza is used to lower triglycerides (fat in your blood) in certain people with very high triglyceride levels. It is also used to lower triglycerides and the risk of acute pancreatitis in certain people with very high triglycerides. Common side effects include pain, itching, swelling, or redness near where you inject it, changes in certain lab tests, and joint pain. Tell your health care provider right away if you have any symptoms of liver problems, such as unusual tiredness, loss of appetite, or yellowing of your skin or eyes. Tryngolza is an injection given under the skin by you, your caregiver, or your health care provider. It is important to follow a low-fat diet while using Tryngolza.
Uses
What is Tryngolza used for?
Tryngolza (olezarsen) is commonly used for the following reasons.
- To lower triglyceride levels (fat in your blood) in people with familial chylomicronemia syndrome (FCS), which is a genetic condition where your body has trouble breaking down fats
To lower triglyceride levels and reduce the risk of acute pancreatitis (inflammation of the pancreas) in people with severe hypertriglyceridemia (very high triglyceride levels)
Navigating Very High Triglycerides With Tryngolza: What You Need to Know
Tryngolza may also be used for other conditions as determined by your health care provider.
How does Tryngolza work (mechanism of action)?
People who have familial chylomicronemia syndrome (FCS) or severe hypertriglyceridemia have very high levels of triglycerides. Tryngolza works by lowering the amount of a protein called apolipoprotein C-III (apoC-III). This protein prevents the breakdown of fats in your blood. Tryngolza lowers apoC-III levels, which helps your body break down fat and lower triglyceride levels. Lowering very high triglycerides may help reduce the risk of acute pancreatitis.
How is Tryngolza supplied (dosage forms)?
Brands and other names
- Tryngolza
Dosage forms and strengths
- 50 mg/0.8 mL autoinjector
- 80 mg/0.8 mL autoinjector
How should I store Tryngolza?
Store Tryngolza in the original carton in the refrigerator between 36 F and 46 F (2 C to 8 C). Once removed from the refrigerator, the medicine can be stored in the carton at room temperature, between 59 F and 86 F (15 C to 30 C) for up to 6 weeks. Throw any unused Tryngolza away after 6 weeks. Do not freeze it or expose it to heat or light.
Side Effects
What are the most common side effects of Tryngolza?
The most common side effects of Tryngolza are listed below. Tell your health care provider if you have any of these side effects that bother you.
- Pain, itching, swelling, or redness near the injection site
- Joint pain or stiffness
- Low platelet levels
- Increased liver enzymes (see below)
There may be other side effects of Tryngolza that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Tryngolza?
While less common, the most serious side effects of Tryngolza are described below, along with what to do if they happen.
Severe Allergic Reactions. Tryngolza may cause allergic reactions, which can be serious. Stop using Tryngolza and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Increased Liver Enzymes. Tryngolza can increase certain liver enzymes and fat in the liver. Keep all appointments with your health care provider for blood work. Call your health care provider right away if you have any of the following symptoms of liver damage.
- Nausea or vomiting
- Stomach or belly pain
- Fever
- Weakness or unusual tiredness
- Itching
- Loss of appetite
- Light-colored poop
- Dark-colored urine (pee)
- Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
Warnings & Precautions
Who should not use Tryngolza?
Allergies to Ingredients. People who are allergic to any of the following should not use Tryngolza.
- Olezarsen
- Tryngolza
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Tryngolza.
What should I know about Tryngolza before using it?
Do not use Tryngolza unless it has been prescribed to you by a health care provider. Use it as prescribed.
Read and follow the “Instructions for Use” that come with Tryngolza. This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Tryngolza. If you have any questions, talk to your health care provider.
Do not share Tryngolza with other people, even if they have the same condition as you. It may harm them.
Keep Tryngolza out of the reach of children. Since this medicine should be kept in a refrigerator before using it, take special precautions to keep it away from children who also use the refrigerator.
You should follow a low-fat diet (no more than 20 grams of fat per day) while using Tryngolza. Talk to your health care provider about ways to do this and foods to limit or avoid.
Keep all appointments, including for blood work, while using Tryngolza.
What should I tell my health care provider before using Tryngolza?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Tryngolza is right for you.
In particular, make sure that you discuss any of the following.
Pregnancy. It is not known if or how Tryngolza could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.
Breastfeeding. It is not known if Tryngolza passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Tryngolza while breastfeeding.
How can I get more information about Tryngolza?
For more information about Tryngolza, you can visit the manufacturer’s website at www.tryngolza.com or call them at 833-644-6647.
Interactions
Does Tryngolza interact with foods or drinks?
There are no known interactions between Tryngolza and foods or drinks.
It is unknown if drinking alcohol will affect Tryngolza. However, alcohol may raise triglyceride levels. It is best to limit the amount of alcohol that you drink.
Does Tryngolza interact with other medicines (drug interactions)?
There are no known interactions between Tryngolza and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
Overdose/Missed Dose
What should I do if I accidentally use too much Tryngolza?
If you or someone else has used too much Tryngolza, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Tryngolza?
If you miss a dose, use it as soon as you remember. Use your next dose one month after giving the missed dose, then continue using it once each month. Do not use double or extra doses.
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