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Overview: Truqap is used to treat certain types of breast cancer or prostate cancer. It works by stopping the signals that help cancer grow. Common side effects include diarrhea, nausea, tiredness, vomiting, mouth sores, and changes in blood test results. Serious side effects may include high blood sugar levels, severe diarrhea, and skin reactions. Call your health care provider right away if you have skin irritation, a new or unusual rash, blisters on the skin, dry mouth, changes in thirst or urination, blurred vision, confusion, or loose, watery stool.

Uses

What is Truqap used for?

Truqap (capivasertib) is commonly used for treating certain types of breast cancer and prostate cancer.

Learn more about Truqap as a targeted therapy for breast cancer.

Truqap for PTEN-Deficient Prostate Cancer: What to Know

Truqap may also be used for other conditions as determined by your health care provider.

How does Truqap work (mechanism of action)?

Truqap is a type of medicine called a kinase inhibitor that blocks the activation of protein kinase (AKT). AKT helps cancer cells to grow and multiply. Truqap blocks the activity of AKT to help stop cancer cells from growing and multiplying. 

How is Truqap supplied (dosage forms)?

Brands and other names

  • Truqap

Dosage forms and strengths

  • 160 mg oral tablets
  • 200 mg oral tablets

How should I store Truqap?

Store Truqap in the original bottle or package at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Truqap?

The most common side effects of Truqap are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Diarrhea (see below)
  • Changes in certain blood cell levels including white blood cells, red blood cells, and platelets
  • Changes in certain blood levels such as creatinine (a measure of how well your kidneys work) and triglycerides
  • High blood sugar levels (see below)
  • Nausea and vomiting
  • Tiredness
  • Rash
  • Dry skin
  • Mouth sores

There may be other side effects of Truqap that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Truqap?

While less common, the most serious side effects of Truqap are described below, along with what to do if they happen.

Severe Allergic Reactions. Truqap may cause allergic reactions, which can be serious. Stop taking Truqap and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Severe Skin Reactions. Truqap can cause a specific type of cutaneous (skin) allergic reaction called DRESS. DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms. It is also sometimes called multi-organ hypersensitivity. This is a reaction that can affect multiple parts of the body including your skin, liver, kidneys, and heart. Stop using the medicine and get help right away if you have any of the following symptoms of this serious skin reaction.

  • Skin rash or pale bumps on the skin called hives
  • Fever or general ill feeling
  • Blisters on lips, eyes, mouth, or skin
  • Swollen lymph nodes
  • Shortness of breath
  • Swelling in your feet, ankles, or legs
  • Dark-colored pee
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Diarrhea. Diarrhea is common with Truqap. Call your health care provider right away at the first sign  of diarrhea. If you are given medicine to prevent or treat diarrhea, take it exactly as your health care provider tells you. They may also tell you to increase your fluid intake. Call your health care provider right away if you have any of the following.

  • Severe diarrhea
  • Diarrhea that does not go away
  • Diarrhea with weakness, dizziness, or fever

High Blood Sugar (Hyperglycemia). Truqap can cause high blood sugar, which can be serious and may lead to death. Your health care provider will monitor your blood sugar levels before you start and during treatment with Truqap. You may need to check your blood sugar more often if you have changes to your diet, exercise regimen or medicines. Call your health care provider right away if you have any of the following symptoms of high blood sugar.

  • Excessive thirst
  • Dry mouth
  • Frequent need to pee
  • Increased appetite with weight loss
  • Confusion
  • Nausea and vomiting
  • Dry skin

Warnings & Precautions

Who should not use Truqap?

Allergies to Ingredients. People who are allergic to any of the following should not take Truqap.

  • Truqap
  • Capivasertib
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Truqap.

What should I know about Truqap before using it?

Do not take Truqap unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Truqap with other people, even if they have the same condition as you. It may harm them.

Keep Truqap out of the reach of children.

Do not chew, cut, or crush Truqap.

What should I tell my health care provider before using Truqap?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Truqap is right for you.

In particular, make sure that you discuss any of the following.

  • Liver problems
  • Kidney problems
  • Skin problems
  • Problems with high blood sugar levels or diabetes

Other Medicines and Supplements. Truqap may interact with other medicines and supplements. Before taking Truqap, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Truqap may cause harm to a fetus. Tell your health care provider if you are or plan to become pregnant. If you become pregnant, stop taking Truqap right away and contact your health care provider. If you can become pregnant, use effective birth control during treatment and for 1 month after your last dose of Truqap. Males with female partners who can become pregnant should use effective birth control during treatment and for 4 months after the last dose of Truqap.

Breastfeeding. Do not take Truqap while you are breastfeeding. It is not known if Truqap passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Truqap?

For more information about Truqap, you can visit the drugmaker's website at www.truqap.com or call them at 800-236-9938.

Interactions

Does Truqap interact with foods or drinks?

Avoid drinking grapefruit juice or eating grapefruit while taking Truqap. Grapefruit may increase the amount of medicine in your body and can raise the risk of side effects.

It is unknown if drinking alcohol will affect Truqap.

Does Truqap interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. 

Some medicines may alter the blood levels of Truqap. Tell your health care provider about all medicines that you take or have recently taken. 

This may not be a complete list of medicines that can interact with Truqap. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally take too much Truqap?

If you or someone else has used too much Truqap, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Truqap?

If you miss a dose, you may still take it within 4 hours from the time you usually take it. If it has been more than 4 hours after you usually take your dose, skip that dose. Take the next dose at your usual time. Do not take 2 doses at the same time to make up for a missed dose.