Trimbow (Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrrolate) - Uses, Side Effects, and More

What are the most common side effects of Trimbow?

The most common side effects of Trimbow are listed below. Tell your health care provider if you have any of these side effects that bother you.

• Bronchitis
• High blood pressure
• Back pain 
• Laryngitis or hoarseness 
• Infection in the nose or throat, sore throat, or common cold symptoms 
• Flu 
• Anemia 
• Muscle spasms
• Discomfort in the mouth and throat
• Sinusitis

There may be other side effects of Trimbow that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Trimbow?

While less common, the most serious side effects of Trimbow are described below, along with what to do if they happen.

Severe Allergic Reactions. Trimbow may cause allergic reactions, which can be serious. Stop using Trimbow and get help right away if you have any of the following symptoms of a serious allergic reaction.

• Breathing problems or wheezing
• Racing heart
• Fever or general ill feeling
• Swollen lymph nodes
• Swelling of the face, lips, mouth, tongue, or throat
• Trouble swallowing or throat tightness
• Itching or skin rash
• Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
• Nausea or vomiting
• Dizziness, feeling lightheaded, or fainting
• Stomach cramps
• Joint pain

Oral Thrush. Trimbow can sometimes cause the mouth and throat to become infected with a type of yeast, a condition known as oral thrush or oral candidiasis. Contact your health care provider if you notice any of the following symptoms of oral thrush. 

• Cracking in the corners of the mouth
• Loss of taste
• Red or white patches in the mouth or throat
• Raised white spots in the mouth or throat

Infections. Trimbow may weaken your immune system and increase your risk of infections, including serious infections. Call your health care provider right away if you have an infection or any of the following symptoms.

• Burning or stinging when you pee 
• Coughing, or coughing up blood
• Fever, sweats, chills, or muscle aches
• Shortness of breath
• Diarrhea or stomach pain
• Weight loss

Reduced Adrenal Function. Long-term use of Trimbow can cause your body’s adrenal glands to stop making as much cortisol (the stress hormone). This is known as adrenal insufficiency. This is especially a concern if you have been taking a corticosteroid by mouth, such as prednisone or methylprednisolone, and you stop it and switch to Trimbow. Adrenal insufficiency can also get worse if your body is under stress because of fever, surgery, or trauma. Contact your health care provider right away if you have the following symptoms of adrenal suppression. Do not stop using your Trimbow.

• Low blood pressure
• Nausea or vomiting
• Weakness, tiredness, or lack of energy

Sudden Breathing Problems. Trimbow may cause the muscles around the airways to tighten (bronchospasm) instead of relaxing, which can be serious. Stop using Trimbow and contact your health care provider right away if your ability to breathe worsens right after using the medicine.

Heart Effects. Trimbow may increase your risk of certain effects on the heart, such as raising your heart rate, blood pressure, or causing an abnormal heart rhythm (arrhythmia). If you measure your blood pressure and the top number (systolic) is 180 mm Hg or higher or the bottom number (diastolic) is 120 mm Hg or higher, get medical attention right away. Also call your health care provider or get medical attention right away if you have chest pain, a fast or irregular heartbeat, or if you feel your heartbeat more than usual.

Weak Bones. Using Trimbow for a long time may cause the bones to become weaker, leading to reduced bone density (osteopenia). It may also cause a more serious condition called osteoporosis, which can cause bones to break (fracture) more easily. Your risk may be higher if you use tobacco, have a family history of osteoporosis, or use certain medicines. Keep all appointments with your health care to check your bone density while you are using Trimbow.     

Eye Problems. Using Trimbow for a long time may increase pressure inside the eye and cause or worsen narrow-angle glaucoma, which can lead to blindness. It may also increase the risk of cataracts or other changes in vision. Keep all appointments for eye exams while using Trimbow. Tell your health care provider right away if you have any of the following symptoms.

• Loss of vision or vision changes, such as blurred vision
• Eye pain or redness
• Severe headache or vomiting
• Seeing bright, colorful circles around lights (vision halos)

Inability to Empty Bladder (Urinary Retention). Trimbow might make it harder to empty your bladder, especially if you already have a blockage or trouble peeing. Stop using Trimbow and call your health care provider right away if you have a hard time peeing or have a weak stream, if peeing is painful, or you are peeing frequently.

Low Potassium Level (Hypokalemia). Trimbow can cause a low potassium level, which can be serious, especially if you take certain other medicines. Keep all appointments for blood work. Call your health care provider if you have any of the following symptoms of a low potassium level.

• Weakness
• Unusual tiredness
• Muscle cramps or twitching
• Constipation

Increased Blood Sugar. Trimbow may increase your blood sugar levels. Talk to your health care provider about how to maintain healthy blood sugar levels.

Nervous System Effects. Trimbow may cause nervous system effects. Contact your health care provider right away if you have symptoms such as a tremor (shaking), nervousness, a fast heart rate, or a feeling of skipped heartbeats. 

Slow Growth. In people who are still growing, such as children and adolescents, Trimbow may slow down growth. Trimbow is not approved for children or adolescents.