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Overview: Rybrevant Faspro is used to treat certain people with a type of lung cancer called non-small cell lung cancer (NSCLC). This medicine is given to you by a health care provider as an injection under your skin over about 5 minutes. Some common side effects include rash, muscle or joint pain, nausea, vomiting, or tiredness. Serious side effects are less common but may include lung, skin, or eye problems. Tell your health care provider right away if you have fever or chills, new or worsening breathing problems, rash or blisters on your skin, or eye dryness, watering, or discharge.

Uses

What is Rybrevant Faspro used for?

Rybrevant Faspro (amivantamab/hyaluronidase-lpuj) is commonly used for certain people with non-small cell lung cancer. 

Rybrevant Faspro may also be used for other conditions as determined by your health care provider.

How does Rybrevant Faspro work (mechanism of action)?

Rybrevant Faspro contains a medicine called amivantamab that binds to two proteins on cancer cells. This prevents those proteins from sending signals that tell cancer cells to grow and multiply. This may make the cancer shrink in size. Rybrevant Faspro also seems to attract certain immune cells to the cancer and helps other immune cells remove important parts of the cancer cell so they do not work properly anymore. Together, these things help your immune system find and destroy cancer cells. 

Rybrevant Faspro also contains hyaluronidase. This ingredient helps allow the medicine amivantamab to reach the cells when it is given as an injection under the skin.

How is Rybrevant Faspro supplied (dosage forms)?

Rybrevant Faspro is available in an injectable form that is given by a health care provider.

How should I store Rybrevant Faspro?

Rybrevant Faspro is usually given by a health care provider in a hospital or clinic. You will not store Rybrevant Faspro at home.

Side Effects

What are the most common side effects of Rybrevant Faspro?

The most common side effects of Rybrevant Faspro are listed below. These side effects may vary depending on the specific drug regimen you take. Tell your health care provider if you have any of these side effects that bother you.

  • Rash
  • Skin redness, swelling, or pain around your fingernails or toenails
  • Muscle or joint pain
  • Nausea, vomiting, diarrhea, or constipation
  • Tiredness
  • Fluid retention, which can be in your hands, feet, ankles, face, or whole body
  • Mouth sores
  • Decreased appetite
  • Headache

There may be other side effects of Rybrevant Faspro that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Rybrevant Faspro?

While less common, the most serious side effects of Rybrevant Faspro are described below, along with what to do if they happen.

Severe Allergic Reactions. Rybrevant Faspro may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Injection Reactions. Rybrevant Faspro can cause reactions that can be serious when it is given to you. These are most common the first time you get a dose of Rybrevant Faspro. Your health care provider will likely give you other medicines to lower your risk of having an injection reaction. Your injection may need to be slowed or stopped if you have these reactions. Tell your health care provider right away if you have any of the following symptoms when you get your injection and for several hours afterward.

  • Fever or chills
  • Redness of your face and neck (flushing)
  • Shortness of breath
  • Chest pain or discomfort
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting

Lung Inflammation. Rybrevant Faspro can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. These symptoms can be similar to your lung cancer symptoms. Get emergency help if you have fever or new or worsening breathing problems, cough, fever, or chest pain. 

Severe Skin Reactions. Rybrevant Faspro can cause a severe skin reaction, called toxic epidermal necrolysis (TEN), that can lead to death if not treated. It can also cause dry skin, itching, and a skin rash that looks like acne. You should use skin cream that does not have alcohol in it while you are using this medicine to reduce your risk of skin reactions. Limit your time in the sun while you are using Rybrevant Faspro and for 2 months after your last dose. Use sunscreen and wear a hat and clothes that cover your skin if you need to be in the sunlight. Use all medicines and products as directed by your health care provider. If you get a rash, call your health care provider right away. Get emergency help if you have any of the following symptoms of TEN.

  • Painful red or purple skin that looks burned and peels off
  • Flat red rash or blisters on your skin, mouth, nose, and genitals
  • Red, painful, watery eyes
  • Flu-like symptoms, including fever, chills, and muscle aches

Severe Eye Problems.Rybrevant Faspro may cause eye problems, such as dry or itchy eyes, redness, blurry vision, vision problems, or inflammation of the eye (uveitis), eyelid (blepharitis), or cornea (keratitis). If you get any new eye problems while using Rybrevant Faspro and you wear contact lenses, you should take them out and use your glasses until you are able to see your eye health care provider about it. Contact your health care provider right away if you have any of the following symptoms.

  • Eye redness, itchiness, or pain
  • Swollen or itchy eyelids 
  • Feeling like you have something in your eye
  • Eye dryness, watering, or discharge
  • Vision changes, such as blurry vision or sensitivity to light

Warnings & Precautions

Who should not use Rybrevant Faspro?

Allergies to Ingredients. People who are allergic to any of the following should not use Rybrevant Faspro.

  • Amivantamab
  • Hyaluronidase
  • Rybrevant Faspro 
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Rybrevant Faspro.

What should I know about Rybrevant Faspro before using it?

Rybrevant Faspro is usually given by a health care provider in a hospital or clinic. The medicine is given to you as an injection under the skin in your stomach area over about 5 minutes. 

If you have used Rybrevant in the past, you may notice that your dose of Rybrevant Faspro is different. Although both Rybrevant and Rybrevant Faspro contain the same active ingredient, these products are different formulations. Rybrevant is given as an infusion into a blood vessel.

Your health care provider may pause your treatment, reduce your dose, or stop Rybrevant Faspro. Tell your health care provider about any side effects that you may get. For example, tell them if you get redness, swelling, or pain around your fingernails or toenails.

Your health care provider will likely give you medicines before each dose of Rybrevant Faspro to lower your risk of having an injection-related reaction. See the Side Effects section for more details. These medicines usually given before each dose include the following. 

  • A medicine for fever, such as acetaminophen (Tylenol)
  • An antihistamine, such as chlorpheniramine or diphenhydramine (Benadryl), which is a medicine commonly used to treat allergy symptoms
  • A corticosteroid, such as dexamethasone, methylprednisolone, or prednisone, which is a medicine for certain inflammatory conditions 

Rybrevant Faspro is often used with other medicines to treat non-small cell lung cancer. There may be other side effects that can happen when medicines are used together, including serious ones. If you are using Rybrevant Faspro with any other medicines to treat your cancer, talk to your pharmacist or other health care provider about any other side effects you may be likely to have. 

What should I tell my health care provider before using Rybrevant Faspro?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Rybrevant Faspro is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Lung problems (other than your lung cancer)
  • Breathing problems

Pregnancy. Rybrevant Faspro may cause harm to a fetus. If you can become pregnant, you may need a test to confirm you are not pregnant before you can start using Rybrevant Faspro. You should use effective birth control while you are using this medicine and for 3 months after your last dose. Tell your health care provider right away if you become pregnant or think you may be pregnant while you are using Rybrevant Faspro. 

Breastfeeding. Do not breastfeed while you are using Rybrevant Faspro and for 3 months after your last dose. It is not known if Rybrevant Faspro passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Rybrevant Faspro?

For more information about Rybrevant Faspro, you can visit the drugmaker’s website at www.rybrevant.com or call them at 800-526-7736.

Interactions

Does Rybrevant Faspro interact with foods or drinks?

There are no known interactions between Rybrevant Faspro and foods or drinks.

It is unknown if drinking alcohol will affect Rybrevant Faspro, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.

Does Rybrevant Faspro interact with other medicines (drug interactions)?

There are no known interactions between Rybrevant Faspro and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Rybrevant Faspro?

If you or someone else has used too much Rybrevant Faspro, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Rybrevant Faspro?

Rybrevant Faspro is usually given by a health care provider in a hospital. Your health care provider will make sure you are receiving Rybrevant Faspro as scheduled.

If you miss an appointment to get your Rybrevant Faspro dose, call to make another appointment as soon as possible.