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Overview: Rezurock is used to treat certain people with chronic graft versus host disease (cGvHD). It works by blocking a substance involved in immune signaling, which helps rebalance the immune response in people with cGvHD. Common side effects include infection, tiredness or weakness, nausea, diarrhea, shortness of breath, cough, swelling, bleeding, and certain types of pain. If you or your partner can become pregnant, you should use effective birth control while taking Rezurock and for one week after the last dose. Rezurock comes as a tablet that is taken by mouth.
 

Uses

What is Rezurock used for?

Rezurock (belumosudil) is commonly used to treat certain people with chronic graft versus host disease (cGvHD). cGvHD is a long-term condition that can happen after bone marrow or stem cell transplants.

Chronic GvHD happens when the cells in the donated tissues (the "graft") attack the healthy cells of the person who received the transplant (the "host"). This can lead to swelling and scar tissue buildup.

Learn more about Rezurock for Chronic Graft Versus Host Disease (GvHD).

Rezurock may also be used for other conditions as determined by your health care provider.

How does Rezurock work (mechanism of action)?

Rezurock blocks a substance in the body called rho-associated coiled-coil kinase (ROCK2). ROCK2 is used by the immune system to send signals. In people with cGvHD, ROCK2 signaling is overactive. By blocking ROCK2, Rezurock helps rebalance the immune system in people with cGvHD, reducing swelling and scar tissue buildup.

How is Rezurock supplied (dosage forms)?

Brands and other names

  • Rezurock

Dosage forms and strengths

  • 200 mg oral tablets

How should I store Rezurock?

Rezurock should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Keep Rezurock in the original bottle with the included packet (desiccant) that protects the tablets from moisture. Be sure the lid of the Rezurock bottle is closed tightly after you take your dose.

Side Effects

What are the most common side effects of Rezurock?

The most common side effects of Rezurock are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Infections
  • Feeling unusually tired or weak
  • Nausea
  • Diarrhea
  • Shortness of breath
  • Cough
  • Fluid retention
  • Bleeding
  • Stomach pain
  • Muscle or joint pain
  • Headache
  • High blood pressure

There may be other side effects of Rezurock that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Rezurock?

While less common, the most serious side effects of Rezurock are described below, along with what to do if they happen.

Severe Allergic Reactions. Rezurock may cause allergic reactions, which can be serious. Stop taking Rezurock and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Rezurock?

Allergies to Ingredients. People who are allergic to any of the following should not take Rezurock.

  • Belumosudil
  • Rezurock
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Rezurock.

What should I know about Rezurock before using it?

Do not take Rezurock unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Rezurock with other people, even if they have the same condition as you. It may harm them.

Keep Rezurock out of the reach of children.

Rezurock should be taken with a meal around the same time each day. The medicine should be swallowed whole with a glass of water. Do not cut, crush, or chew Rezurock.

You will need to have blood work done while taking Rezurock. Keep all appointments for blood work so your health care provider can make sure it is safe for you to take this medicine.

Rezurock may make it hard for you to get pregnant or get your partner pregnant. If you have concerns, talk to your health care provider.

What should I tell my health care provider before using Rezurock?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Rezurock is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Kidney problems
  • Liver problems

Other Medicines and Supplements. Rezurock may interact with other medicines and supplements. Before taking Rezurock, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Rezurock may cause harm to a fetus. You must not be pregnant before starting Rezurock. Tell your health care provider if you are or plan to become pregnant. If you or your partner can become pregnant, you should use effective birth control during treatment with Rezurock and for one week after your last dose.   

Breastfeeding. It is not known if Rezurock passes into breast milk. Do not breastfeed during treatment with Rezurock and for one week after your last dose. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Rezurock?

For more information about Rezurock, you can visit the drugmaker's website at www.rezurock.com or call them at 800-633-1610.

Interactions

Does Rezurock interact with foods or drinks?

Rezurock should be taken with a meal. Food can increase the levels of Rezurock in your body. 

Taking Rezurock with foods or beverages that contain caffeine (such as coffee, tea, soda, chocolate, and some protein bars) may increase caffeine levels in your body and increase your risk of caffeine side effects. 

It is unknown if drinking alcohol will affect Rezurock, but drinking alcohol can worsen cGvHD.

Does Rezurock interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are taking a proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex).

Many other medicines may alter the blood levels of Rezurock, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Rezurock. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Rezurock?

If you or someone else has used too much Rezurock, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Rezurock?

If you miss a dose of Rezurock, take the dose as soon as you remember, as long as it is still the same day. If it is close to the time for the next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.