Overview: Insulin regular is a short-acting insulin used to lower blood sugar levels in people with diabetes. It works by helping sugar (glucose) in the blood move into cells so the body can use the sugar for energy. It also reduces sugar production by the liver. Common side effects include low blood sugar, weight gain, and pain, redness, itching, or swelling at the injection site. Contact your health care provider right away if you have severe or frequent low blood sugar or if you feel weak or unusually tired. Insulin regular is a liquid that is injected, and it comes in a vial or pen device in multiple strengths. Before you inject any insulin, check the label to be sure you are using the right product and dose.
Uses
What is insulin regular used for?
Insulin regular is commonly used to help lower blood sugar levels in people with type 1 diabetes or type 2 diabetes.
Insulin regular may also be used for other conditions as determined by your health care provider.
How does insulin regular work (mechanism of action)?
Insulin regular regulates how your body uses blood sugar (glucose). Insulin regular helps get blood sugar into your cells so your body can use it for energy, prevents your liver from making blood sugar, and enhances the creation of protein in your tissues.
How is insulin regular supplied (dosage forms)?
Brands and other names
- Humulin R
- Humulin R KwikPen
- Myxredlin
- Novolin R
- Novolin R FlexPen
- ReliOn
- ReliOn FlexPen
Dosage forms and strengths
- 100 units/mL, 500 units/mL vial
- 100 units/mL FlexPen
- 500 units/mL KwikPen
How should I store insulin regular?
Store insulin regular in a place that is not exposed to direct sunlight and heat. Do not freeze. Before opening the vials or pens, insulin regular should be stored in a refrigerator, between 36 F and 46 F (2 C and 8 C). If it is stored in the refrigerator, it can be used up until the expiration date on the package. Insulin regular may also be stored at room temperature before or after first use, but it should be thrown away after a certain period of time, depending on the product. Talk to your pharmacist about how to store your insulin regular vials or pens, and about how long you can use your specific product once it has been opened.
Store FlexPens or KwikPens without the needle attached.
Side Effects
What are the most common side effects of insulin regular?
The most common side effects of insulin regular are listed below. Tell your health care provider if you have any of these side effects that bother you.
- Low blood sugar (see below)
- Allergic reactions, such as itching and rash (see below)
- Pain, itching, swelling, or redness near the injection site
- Skin thickening or pits at the injection site (lipodystrophy)
- Weight gain
- Fluid retention in the hands or feet (edema)
There may be other side effects of insulin regular that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of insulin regular?
While less common, the most serious side effects of insulin regular are described below, along with what to do if they happen.
Severe Allergic Reactions. Insulin regular can cause allergic reactions, which can be serious. Stop using insulin regular and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Low Blood Sugar (Hypoglycemia). Insulin regular can cause low blood sugar, also called hypoglycemia, which can be serious and may lead to death. You may need to check your blood sugar more often if you have changes to your diet, exercise regimen, or medicines for diabetes. Do not use insulin regular and call your health care provider right away if you have any of the following symptoms of hypoglycemia.
- Headache
- Crankiness or anxiety
- Hunger
- Dizziness or confusion
- Blurry vision
- Slurred speech
- Sweating
- Feeling jittery or shakiness
- Fast heartbeat
- Seizures
Low Potassium Level (Hypokalemia). Insulin regular can cause a low potassium level (hypokalemia), which can be serious and may lead to death. Your health care provider may check your potassium levels, especially if you take certain other medicines. Call your health care provider if you have any of the following symptoms of a low potassium level.
- Weakness
- Unusual tiredness
- Muscle cramps or twitching
- Constipation
- Abnormal heart rhythm
- Trouble breathing
Warnings & Precautions
Who should not use insulin regular?
Allergies to Ingredients. People who are allergic to any of the following should not use insulin regular.
- Insulin regular
- Humulin R
- Myxredlin
- Novolin R
- ReliOn
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in the specific insulin regular products they stock.
Low Blood Sugar (Hypoglycemia). Insulin regular should not be used when you have low blood sugar. Be familiar with the symptoms of low blood sugar, including dizziness, sweating, confusion, and shakiness. Ask your health care provider about your blood sugar levels and when to check them.
What should I know about insulin regular before using it?
Do not use insulin regular unless it has been prescribed to you by a health care provider. Use it as prescribed. Any changes in your insulin regimen can increase your risk of having high or low blood sugar. Follow all instructions from your health care provider, including how often to check your blood sugar.
Do not share insulin regular with other people, even if they have the same condition as you. It may harm them. Do not reuse or share needles or syringes with another person because you may get a serious infection. Always use a new needle or syringe for each injection.
Keep insulin regular out of the reach of children. Since this medicine may be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.
This medicine is injected under the skin. There are multiple forms of insulin regular available. Read and follow the instructions for the product you have and make sure you understand how to prepare and use it properly. If you have any questions, talk to your health care provider.
If you are using multiple insulin products, accidentally mixing them up and using the wrong insulin or the wrong dose can cause low blood sugar. Always check the label on your insulin products before using them to make sure you are using the correct insulin and dose. Call your health care provider right away if you have any symptoms of low blood sugar.
Do not use the same exact spot for each injection of insulin regular. This can increase your risk of having pits or lumps where the medicine is injected. Do not inject where your skin is thickened, lumpy, bruised, tender, hard, or damaged.
Insulin regular can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how insulin regular affects you.
What should I tell my health care provider before using insulin regular?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if insulin regular is right for you.
In particular, make sure that you discuss any of the following.
Other Medicines and Supplements. Insulin regular may interact with other medicines and supplements. Before using insulin regular, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Current and Past Health Conditions. Tell your health care provider if you have any of the following.
- Kidney or liver problems
- Heart problems (including heart failure)
- Unable to tell when you have low blood sugar
Diet and Lifestyle Changes. Tell your health care provider if you have any changes in your diet, level of physical activity, or illnesses. These may affect the amount of insulin regular you need.
Pregnancy. Insulin regular has not been shown to cause harm to a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should use insulin regular while you are pregnant or trying to get pregnant. Uncontrolled diabetes can increase the risk of harm to a mother and fetus. Talk with your health care provider about the best way to manage your blood sugar.
Breastfeeding. Insulin regular may pass into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use insulin regular while breastfeeding.
Interactions
Does insulin regular interact with foods or drinks?
It is unknown if drinking alcohol will affect insulin regular, but alcohol may affect blood sugar levels in people with diabetes. This may interfere with the effect of insulin regular. Do not drink alcohol or use any medicines that have alcohol in them while using insulin regular.
Does insulin regular interact with other medicines (drug interactions)?
Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are taking a beta-blocker, which is a medicine usually used to reduce blood pressure and for certain other heart conditions, before using insulin regular.
Many other medicines may alter your blood sugar levels or may increase or decrease the effect of insulin regular. Tell your health care provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with insulin regular. Always check with your health care provider.
Overdose/Missed Dose
What should I do if I accidentally use too much insulin regular?
If you or someone else has used too much insulin regular, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of insulin regular?
It is important to use your insulin regular exactly as it is prescribed. Talk to your health care provider ahead of time about what you should do if you miss a dose of insulin regular. Do not use double or extra doses.
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