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Overview: Rasonque is used to treat advanced pancreatic cancer. It blocks proteins that help cancer cells grow and survive. Common side effects include rash, diarrhea, mouth sores, nausea, and tiredness. Contact your health care provider right away if you have new or worsening diarrhea, breathing problems, or skin reactions. Rasonque is a tablet that is taken by mouth.

Uses

What is Rasonque used for?

Rasonque (daraxonrasib) is commonly used to treat pancreatic cancer that has spread in certain people.

What to Know About Rasonque for Pancreatic Cancer

Rasonque may also be used for other conditions as determined by your health care provider.

How does Rasonque work (mechanism of action)?

Rasonque works by blocking RAS proteins, which help control cell growth and can become overactive in some cancers. By shutting down these proteins, Rasonque can slow cancer cell growth and may cause cancer cells to die.

How is Rasonque supplied (dosage forms)?

Brands and other names

  • Rasonque

Dosage forms and strengths

  • 100 mg oral tablets
  • 150 mg oral tablets

How should I store Rasonque?

Store Rasonque at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Rasonque?

The most common side effects of Rasonque are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Rash (see Skin Reactions below)
  • Diarrhea (see below)
  • Mouth sores (see below)
  • Nausea or vomiting
  • Tiredness
  • Stomach pain
  • Fluid retention
  • Low appetite
  • Bleeding
  • Changes in certain lab tests, such as decreased levels of electrolytes, white blood cells, and platelets, and increased levels of liver enzymes

There may be other side effects of Rasonque that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Rasonque?

While less common, the most serious side effects of Rasonque are described below, along with what to do if they happen.

Severe Allergic Reactions. Rasonque may cause allergic reactions, which can be serious. Stop taking Rasonque and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Skin Reactions. Rasonque can cause skin reactions that may be severe. These reactions may include rash, itching, dry or cracked skin, or swelling and irritation around the nails. Your health care provider may recommend creams, sunscreen, or medicines to help prevent or manage these reactions. Limit sun exposure while taking Rasonque, and contact your health care provider right away if you have new or worsening skin problems.

Mouth Sores. Rasonque can cause sores or inflammation in your mouth (stomatitis). Your health care provider may recommend certain medicines to manage this side effect. Tell your health care provider right away if you have new or worsening sores, pain, or irritation in your mouth while taking Rasonque.

Diarrhea. Diarrhea is common with Rasonque and can sometimes be severe. If your health care provider recommends medicine to help prevent or treat diarrhea, take it exactly as directed. Call your health care provider right away if you have new or worsening symptoms of diarrhea.

Gut Damage. While rare, Rasonque may cause a hole or tear (perforation) in the stomach or intestines. This can be serious or life-threatening. Contact your health care provider right away if you have any of the following symptoms.

  • Stomach pain or tenderness that feels severe or does not go away
  • Nausea or vomiting that does not go away or throwing up blood
  • Fever or chills
  • Bloody, black, or tar-like poop

Lung Inflammation. Rasonque can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. Get emergency help if you have trouble breathing. You may also have a cough, fever, wheezing, or shortness of breath. 

Warnings & Precautions

Who should not use Rasonque?

Allergies to Ingredients. People who are allergic to any of the following should not take Rasonque.

  • Daraxonrasib
  • Rasonque
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Rasonque.

What should I know about Rasonque before using it?

Do not take Rasonque unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Rasonque with other people, even if they have the same condition as you. It may harm them.

Keep Rasonque out of the reach of children.

Do not chew, crush, or split Rasonque. Swallow the tablets whole.

Rasonque commonly causes skin reactions, such as rash, itching, and dry skin. Starting before your first dose, you can help lower your risk of severe reactions by keeping your skin moisturized, limiting time in the sun, and using any creams or medicines your health care provider recommends. If you need to be in sunlight, wear sunscreen, a hat, and clothing that covers your skin. If you get a new rash, tell your health care provider right away.

Do not miss any medical appointments, including labs or other testing, while taking Rasonque. If you miss an appointment, contact the office to reschedule as soon as possible. 

What should I tell my health care provider before using Rasonque?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Rasonque is right for you.

In particular, make sure that you discuss any of the following.

Other Medicines and Supplements. Rasonque may interact with other medicines and supplements. Before taking Rasonque, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Rasonque may cause harm to a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. If you can get pregnant, your health care provider will give you a pregnancy test to make sure you are not pregnant before starting treatment. If you are able to get pregnant, you should use effective birth control while taking Rasonque and for 1 week after your last dose. Also, males with female partners who can become pregnant should use effective birth control (such as condoms) while taking Rasonque and for 1 week after the last dose.

Breastfeeding. It is not known if Rasonque passes into breast milk. You should not breastfeed while taking Rasonque and for 1 week after your last dose. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Rasonque?

For more information about Rasonque, you can visit the drugmaker’s website at www.rasonque.com or call them at 844-2-REVMED (844-273-8633).

Interactions

Does Rasonque interact with foods or drinks?

Ask your health care provider if you should avoid eating grapefruit or drinking grapefruit juice while taking Rasonque. The combination may increase blood levels of the medicine, possibly raising the risk of side effects. 

It is unknown if drinking alcohol will affect Rasonque, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.

Does Rasonque interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Rasonque.

  • Cyclosporine (Gengraf, Neoral, Sandimmune, and others), which is a medicine that suppresses your immune system
  • Fluconazole (Diflucan), itraconazole (Sporanox, Tolsura), or voriconazole (Vfend), which is a medicine used for fungal infections
  • Verapamil (Verelan, Verelan PM), which is a medicine used for high blood pressure or heart conditions
  • Quinidine, which is a medicine used to treat malaria or control your heart rate or rhythm
  • Phenytoin, which is a medicine used for seizures
  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • Efavirenz, which is a medicine used for HIV
  • Dabigatran, which is a blood thinner used to help prevent and treat blood clots
  • Modafinil (Provigil), which is a medicine used to help people stay awake if they have certain sleep disorders

Many other medicines may alter the blood levels of Rasonque, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Rasonque. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Rasonque?

If you or someone else has used too much Rasonque, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Rasonque?

If you miss a dose by less than 4 hours, take it as soon as you remember. If you miss a dose by more than 4 hours, skip it and take your next dose at the usual time. Do not take double or extra doses. 

If you vomit after taking a dose, do not take another dose; wait until your next scheduled dose.