Vagistat Products for Vaginal Yeast Infections

Written by Beth Johnston, BCPS, PharmD
Medically Reviewed by Laurel Riemann, PharmD on November 14, 2025

Vagistat products are used to treat vaginal yeast infections. The active ingredient in most Vagistat products is miconazole. Vagistat 1-Dose contains tioconazole instead of miconazole. Both miconazole and tioconazole are antifungal medicines. They work by stopping the fungus (yeast) that is causing the infection.

There are Vagistat products for adults and children as young as 12 years old.

Side effects may vary depending on the ingredients in the specific product you are using. Some possible side effects include burning, itching, or irritation when you use it.

Since Vagistat products may contain different active ingredients (listed below), review the ingredients in your specific product to understand which side effects you might experience.

Stop using the medicine if you develop a rash or hives. Get medical help right away if you have signs of a serious allergic reaction, such as trouble breathing or swelling of the face, lips, or throat.

Vagistat products for yeast infections are for vaginal and external use only. You should not swallow any of these products.

Some Vagistat products come with an itch relief cream for external use. These creams are not inserted into your vagina and are to help with your symptoms. Insertion of the medicine into your vagina is needed to cure a vaginal yeast infection.

You will use the applicator that comes with your Vagistat product to place the ointment, cream, or suppository into your vagina. If you will use a three-day or seven-day product, use a new applicator each day. This means that you will throw away the applicator after you use it to place the medicine into your vagina.

Check with your health care provider before using a Vagistat product for a yeast infection if any of the following apply to you.

  • This is the first time you have vaginal itching or discomfort
  • You also have pain in your lower stomach area, back, or shoulders, fever, chills, nausea, or vomiting or your vaginal discharge smells bad
  • You get frequent vaginal yeast infections (such as once a month or three infections in six months)
  • You have been exposed to HIV
  • You are pregnant or breastfeeding
  • You take warfarin, which is a blood thinner
  • You are peeing a lot or have an urgent need to pee or trouble peeing
  • You have diabetes

When you are using a Vagistat product for a vaginal yeast infection, you should not do any of the following:

  • Have vaginal intercourse
  • Use tampons, douches, spermicides, or other vaginal products

If you do have vaginal intercourse during or shortly after completing your treatment with a Vagistat product, do not rely on either condoms or diaphragms. Vagistat products are oil-based. This means that they may weaken latex condoms and diaphragms. Weakened condoms or diaphragms may not prevent pregnancy or sexually transmitted infections.

 

Stop using your Vagistat product for a vaginal yeast infection and contact your health care provider if any of the following apply to you.

  • Your symptoms are not improving within three days
  • Your symptoms last longer than seven days
  • You get pain in your lower stomach area, fever, chills, nausea, vomiting, or vaginal discharge that smells bad

There may be side effects, additional warnings, and interactions with other medicines that are not listed here. These may vary depending on the combination of ingredients in the specific Vagistat product you are using. Always check the label before using any over-the-counter medicine. Do not use more than the recommended dose. Talk to your doctor or pharmacist about your health conditions and other medicines to help determine which products are safe for you.

Vagistat products vary by active ingredients and dosage forms. All Vagistat products can be used in adults and children as young as 12 years old. Use the table below to help you decide which Vagistat product is best for you. Note that bedtime dosing is recommended for all of these Vagistat products.

ProductActive Ingredient and Use
Vagistat 1-Dose Treatment
  • Tioconazole 6.5% ointment 
  • Insert prefilled applicator vaginally.
Vagistat 3-Day Treatment Combination Pack
  • Miconazole 200 mg suppository and miconazole 2% cream
  • Insert one suppository vaginally each day for 3 days using a disposable applicator.
  • Apply cream externally twice daily for up to 7 days, as needed.
Vagistat 7-Day Treatment
  • Miconazole 2% cream 
  • Fill one disposable applicator full of cream and insert vaginally each day for 7 days.
  • Apply cream externally twice daily for up to 7 days, as needed.