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Overview: Nereus is a medicine taken to prevent vomiting from motion sickness. It comes as a capsule that you swallow. Common side effects may include drowsiness, feeling tired, or headache. You should not drive or do other tasks that require you to be fully alert until you know how Nereus affects you. Nereus can interact with other medicines. Make sure to tell your health care provider about all the medicines you take.

Uses

What is Nereus used for?

Nereus (tradipitant) is commonly used to prevent vomiting (antiemetic) associated with motion sickness.

Learn more about Nereus for motion sickness.

Nereus may also be used for other conditions as determined by your health care provider.

How does Nereus work (mechanism of action)?

Motion sickness happens when the brain receives mixed signals that can cause nausea and vomiting. One of the chemicals involved in these signals is called substance P. Nereus is thought to work by blocking the effects of substance P. This helps prevent vomiting from motion sickness.

How is Nereus supplied (dosage forms)?

Brands and other names

  • Nereus

Dosage forms and strengths

  • 85 mg oral capsules

How should I store Nereus?

Nereus should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place and protect from light.

Side Effects

What are the most common side effects of Nereus?

The most common side effects of Nereus are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Drowsiness or tiredness
  • Headache

There may be other side effects of Nereus that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Nereus?

While less common, the most serious side effects of Nereus are described below, along with what to do if they happen.

Severe Allergic Reactions. Nereus may cause allergic reactions, which can be serious. Stop taking Nereus and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Decreased Alertness or Coordination. Nereus can affect your alertness or coordination. This may be more common if you take certain medicines. Do not drive or do other activities that require alertness or coordination until you know how Nereus affects you.

Warnings & Precautions

Who should not use Nereus?

Allergies to Ingredients. People who are allergic to any of the following should not take Nereus.

  • Nereus
  • Tradipitant
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Nereus.

What should I know about Nereus before using it?

Do not take Nereus unless it has been prescribed to you by a health care provider. Take it as prescribed.

You should take Nereus about 1 hour before doing an activity that is likely to cause motion sickness. This gives the medicine time to start working. If you have any questions about how to take Nereus, talk to your health care provider. 

Do not share Nereus with other people, even if they have the same condition as you. It may harm them.

Keep Nereus out of the reach of children.

Nereus can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Nereus affects you.

What should I tell my health care provider before using Nereus?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Nereus is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

Pregnancy. It is not known if or how Nereus could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. Nereus may pass into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Nereus while breastfeeding. If you do take Nereus while breastfeeding, monitor your child for increased sleepiness. 

How can I get more information about Nereus?

For more information about Nereus, you can visit the drugmaker’s website at www.vandapharma.com or call them at 202-734-3400.

Interactions

Does Nereus interact with foods or drinks?

Nereus should be taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal.

The risk of drowsiness or tiredness may be increased if you drink alcohol while taking Nereus.

Does Nereus interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, or medicines for anxiety before taking Nereus.

Some other medicines may alter the blood levels of Nereus. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Nereus. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Nereus?

If you or someone else has taken too much Nereus, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Nereus?

Nereus is meant to be taken only when needed. Take it as your health care provider recommends. Do not take double or extra doses.