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Overview: Myqorzo is used to treat certain people with a heart problem called obstructive hypertrophic cardiomyopathy. Myqorzo may increase your blood pressure, so keep an eye on your readings if you have high blood pressure. Do not start, stop, or change the dose of anything you use unless told to do so by your health care provider. Tell your health care provider right away if you get any unusual swelling, tiredness, or weight gain. Get emergency help if you have chest pain or trouble breathing.

Uses

What is Myqorzo used for?

Myqorzo (aficamten) is commonly used for certain people with obstructive hypertrophic cardiomyopathy (HCM). HCM is a heart condition where part of the heart muscle thickens over time.

Learn more about Myqorzo for Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Myqorzo may also be used for other conditions as determined by your health care provider.

How does Myqorzo work (mechanism of action)?

Your heart is a muscle that pumps blood throughout your body. Your heart relaxes to fill with blood and contracts to push blood out. If your heart muscle is thickened, your heart has a harder time pumping blood. If the thickened muscle blocks blood flow from the heart, you have a condition called obstructive hypertrophic cardiomyopathy.

Myqorzo is known as a cardiac myosin inhibitor. Myosin is a protein that is needed for your heart to contract. Myqorzo works to reduce heart contractility. As a result, your heart is better able to push blood out to your body.

How is Myqorzo supplied (dosage forms)?

Brands and other names

  • Myqorzo

Dosage forms and strengths

  • 5 mg, 10 mg, 15 mg, 20 mg oral tablets

How should I store Myqorzo?

Myqorzo should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Myqorzo?

The most common side effect of Myqorzo is high blood pressure. Tell your health care provider if you have any side effects that bother you.

There may be other side effects of Myqorzo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Myqorzo?

While less common, the most serious side effects of Myqorzo are described below, along with what to do if they happen.

Severe Allergic Reactions. Myqorzo may cause allergic reactions, which can be serious. Stop taking Myqorzo and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Heart Failure. Myqorzo may increase your risk of heart failure, which can be life-threatening. The risk can be higher if you are taking certain medicines, have a serious infection, or have an irregular heartbeat. You will need an exam called an echocardiogram before and during your treatment with Myqorzo. Keep all appointments to have your heart checked. Myqorzo may need to be stopped or your dose may need to be reduced. Tell your health care provider right away or get emergency help if you have any of the following symptoms of heart failure.

  • Chest pain
  • Fast heartbeat (racing sensation or feeling)
  • Shortness of breath or trouble breathing, especially while lying down
  • Swelling in your feet, ankles, or legs
  • Unusually fast weight gain
  • Unusual tiredness

Warnings & Precautions

Who should not use Myqorzo?

Allergies to Ingredients. People who are allergic to any of the following should not take Myqorzo.

  • Aficamten
  • Myqorzo
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Myqorzo.

Drug Interactions. Myqorzo should not be taken while you are using certain other medicines. Before taking Myqorzo, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Myqorzo before using it?

Do not take Myqorzo unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Myqorzo with other people, even if they have the same condition as you. It may harm them.

Keep Myqorzo out of the reach of children.

Myqorzo is only available through a special program, from certain pharmacies, and to certain people. If you have any questions about this program you can go to www.myqorzorems.com or call 844-285-7367.

Swallow Myqorzo whole. Do not cut, crush, or chew the tablets. Consider using an alarm to help you take this medicine at the same time each day. 

Myqorzo interacts with many medicines. Do not start, stop, or change the dose of any medicine or supplement while you are taking Myqorzo unless told to do so by your health care provider. Make sure that all of your health care providers know everything that you take, including Myqorzo.

If you get certain side effects, your health care provider may pause your treatment, reduce your dose, or stop Myqorzo. Tell your health care provider right away about any symptoms that you may get, especially those that may be caused by heart failure. See the Side Effects section for more details.

Your dose of Myqorzo may change based on several things. One is how well your heart is pumping blood. It is important that you keep all of your appointments, including labs or other testing, while taking Myqorzo. Do not change your dose on your own. Carefully follow all directions from your health care provider.

What should I tell my health care provider before using Myqorzo?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Myqorzo is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

Pregnancy. It is not known if or how Myqorzo could affect pregnancy or harm an unborn baby. Tell your health care provider if you plan to become pregnant. Your health care provider will let you know if you should take Myqorzo while you are pregnant or trying to get pregnant. Tell your health care provider right away if you become pregnant while taking this medicine or within 3 weeks of stopping it. Your health care provider may contact the drugmaker, as a pregnancy safety study exists to collect information about the use of Myqorzo during pregnancy.

Breastfeeding. It is not known if Myqorzo passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Myqorzo while breastfeeding.

How can I get more information about Myqorzo?

For more information about Myqorzo, you can visit the drugmaker’s website at www.myqorzo.com or call them at 833-697-6796.

Interactions

Does Myqorzo interact with foods or drinks?

There are no known interactions between Myqorzo and foods or drinks.

It is unknown if drinking alcohol will affect Myqorzo.

Does Myqorzo interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Myqorzo.

  • Fluvoxamine (Luvox), which is a medicine commonly used for obsessive-compulsive disorder (OCD)
  • Fluconazole (Diflucan) or voriconazole (Vfend), which is a medicine used for fungal infections
  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • Carbamazepine (Carbatrol, Tegretol, and others), which is a medicine commonly used to treat seizures or nerve pain

Many other medicines may alter the blood levels of Myqorzo. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Myqorzo. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Myqorzo?

If you or someone else has used too much Myqorzo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Myqorzo?

If you miss a dose, take it as soon as you remember on the same day. Take your next dose, the following day at your usual time. Do not take two doses on the same day.