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Overview: Icotyde is used to treat a skin condition called plaque psoriasis. It works by reducing inflammation. Common side effects may include headache, nausea, cough, fungal infections, and tiredness. Icotyde may increase the risk of infections. Contact your health care provider right away if you think you have an infection while taking Icotyde. Icotyde is a tablet that can be swallowed whole or dispersed in water and taken as a liquid mixture.

Uses

What is Icotyde used for?

Icotyde (icotrokinra) is commonly used to treat certain people with plaque psoriasis.

Learn more about Treating Plaque Psoriasis With Icotyde.

Icotyde may also be used for other conditions as determined by your health care provider.

How does Icotyde work (mechanism of action)?

Icotyde works by blocking a receptor in the body that binds to a natural substance that causes inflammation. This helps reduce inflammation and can improve symptoms of plaque psoriasis.

How is Icotyde supplied (dosage forms)?

Icotyde is available in a 200 mg oral tablet that is taken by mouth.

How should I store Icotyde?

Icotyde should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store Icotyde in the original bottle to protect it from moisture. Keep the desiccant (a small packet that helps absorb moisture) in the bottle.

Side Effects

What are the most common side effects of Icotyde?

The most common side effects of Icotyde are listed below. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of Icotyde that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Icotyde?

While less common, the most serious side effects of Icotyde are described below, along with what to do if they happen.

Severe Allergic Reactions. Icotyde may cause allergic reactions, which can be serious. Stop taking Icotyde and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infections. Icotyde can increase your risk of infections. Call your health care provider right away if you have an infection or any of the following symptoms.

  • Burning or pain when you pee 
  • Fever or chills
  • Body aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Weight loss
  • Cough or coughing up blood
  • New or unusual pain, warmth, or sores on your skin

Warnings & Precautions

Who should not take Icotyde?

Allergies to Ingredients. People who are allergic to any of the following should not take Icotyde.

  • Icotrokinra
  • Icotyde
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Icotyde.

What should I know about Icotyde before taking it?

Do not take Icotyde unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Icotyde with other people, even if they have the same condition as you. It may harm them.

Keep Icotyde out of the reach of children.

Do not crush, cut, or chew Icotyde.

If you have trouble swallowing Icotyde whole, you can place one tablet in at least 4 ounces (120 milliliters) of water for a few minutes and let it break apart. The mixture may look cloudy or have small pieces, which are safe to swallow. Swirl gently and drink all of it, then add another 4 ounces of water, swirl, and drink again to get the full dose. Take it within 15 minutes of mixing.

What should I tell my health care provider before taking Icotyde?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Icotyde is right for you.

In particular, make sure that you discuss any of the following.

Tuberculosis. Your health care provider may check you for tuberculosis (TB) before you start Icotyde. Do not take Icotyde if you have active TB. Tell your health care provider if you have been in close contact with someone who has TB. If you have had TB in the past, your health care provider may treat it before you start Icotyde.

Other Infections. Icotyde may affect your immune system and make your body less able to fight infections. Before taking Icotyde, tell your health care provider if you have an infection now, or if you have an infection that will not go away or keeps coming back. 

Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines while taking Icotyde. Tell your health care provider about any vaccines you have recently received or have scheduled.

Kidney Problems. Tell your health care provider if there is a concern about the health of your kidneys. They may do tests to see how well your kidneys are working. Kidney problems may increase the risk of Icotyde side effects. 

Breastfeeding. It is not known if Icotyde passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Icotyde while breastfeeding. 

Pregnancy. It is not known if or how Icotyde could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should take Icotyde while you are pregnant or trying to get pregnant. 

If you become pregnant while taking Icotyde, you can sign up for a pregnancy safety study by calling 800-526-7736 or at www.icotyde.com. This study collects safety information about the use of Icotyde during pregnancy.

How can I get more information about Icotyde?

For more information about Icotyde, you can visit the drugmaker’s website at www.icotyde.com or call them at 800-526-7736.

Interactions

Does Icotyde interact with foods or drinks?

Take Icotyde on an empty stomach with water upon waking, then wait at least 30 minutes before eating.

It is unknown if drinking alcohol will affect Icotyde. 

Does Icotyde interact with other medicines (drug interactions)?

Icotyde may interact with certain vaccines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Icotyde?

If you or someone else has used too much Icotyde, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Icotyde?

If you miss a dose, take it as soon as you remember. Then go back to your regular dosing schedule the next day. Do not take double or extra doses.