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Overview: Flurandrenolide is used to treat skin conditions that involve inflammation and itchiness. Common side effects from flurandrenolide are skin reactions, such as redness, pain, and inflammation. Do not bandage, wrap, or otherwise seal the area where flurandrenolide is used unless your health care provider instructed you to do so. Doing this could increase the amount of flurandrenolide in your blood and possibly increase side effects.

Uses

What is flurandrenolide used for?

Topical flurandrenolide is commonly used to treat skin conditions that cause inflammation and itchiness.

Flurandrenolide may also be used for other conditions as determined by your health care provider.

How does flurandrenolide work (mechanism of action)?

Flurandrenolide belongs to a group of medicines called corticosteroids. Topical corticosteroids may help reduce inflammation in your skin by calming down the immune system's defense cells (white blood cells). They may also stop these cells from releasing substances that cause inflammation. These medicines may also narrow blood vessels where they are applied, which may help to reduce swelling.

How is flurandrenolide supplied (dosage forms)?

Brands and other names

  • Cordran

Dosage forms and strengths

  • 0.05% topical cream
  • 0.05% topical lotion
  • 0.05% topical ointment
  • 4 mcg per sq cm topical tape

How should I store flurandrenolide?

Topical flurandrenolide should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. The topical tape should be stored in the original container and should be protected from moisture. Keep the lid of the vial containing the tape tightly closed.

Side Effects

What are the most common side effects of flurandrenolide?

The most common side effects of flurandrenolide are skin reactions (see below). These reactions can include dryness, burning, irritation, itchiness, and inflamed hair follicles. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of flurandrenolide that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of flurandrenolide?

While less common, the most serious side effects of flurandrenolide are described below, along with what to do if they happen.

Severe Allergic Reactions. Flurandrenolide may cause allergic reactions, which can be serious. Stop using flurandrenolide and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Reduced Adrenal Function. Flurandrenolide can pass through your skin and cause your body’s adrenal glands to stop making as much cortisol (the stress hormone). This is known as adrenal insufficiency. This is especially a concern if you use flurandrenolide over large skin areas or for a long period of time, wrap or cover the skin after applying flurandrenolide, or use flurandrenolide on damaged skin. Adrenal insufficiency can get worse if your body is under stress because of fever, surgery, or trauma. Tell your health care provider if you have any of the following symptoms of adrenal insufficiency.

  • Nausea and vomiting
  • Weakness, tiredness, or lack of energy
  • Low blood pressure

Cushing’s Syndrome. Flurandrenolide can cause Cushing’s syndrome, a condition that happens when your body is exposed to too much cortisol (the stress hormone). This is especially a concern if you use flurandrenolide over large skin areas or for a long period of time, wrap or cover the skin after applying flurandrenolide, or use flurandrenolide on damaged skin. Tell your health care provider if you notice any of the following symptoms.

  • Rounded, rosy face
  • Weight gain, especially in the upper body
  • Thinning of skin
  • Acne
  • Unusual tiredness or weakness
  • Depressed mood or anxiety
  • Kidney stones
  • Sleep problems
  • Unusual hair growth

High Blood Sugar. Flurandrenolide may increase your blood sugar levels, especially if you use flurandrenolide over large skin areas or for a long period of time, wrap or cover the skin after applying flurandrenolide, or use it on damaged skin. It may also cause your body to leak sugar into your urine (pee). Keep all appointments with your health care provider to check your blood work. Talk to your health care provider about how to maintain healthy blood sugar levels. Call your health care provider if you have the following symptoms of high blood sugar.

  • Thirsty more than usual
  • Peeing more than usual
  • Increase in hunger
  • Tiredness
  • Feeling sick to your stomach
  • Confusion
  • Your breath smelling fruity

Skin Reactions. Flurandrenolide may cause skin-related side effects. Tell your health care provider if you have any of the following side effects.

  • Inflamed hair follicles or skin swelling or burning
  • Bumps or blisters on the skin that may look like acne
  • Rash around your mouth
  • Lightening of skin color
  • Skin infections at the site of use
  • Skin thinning
  • Skin itching, dryness, cracking, or scaly skin
  • Stretch marks
  • Heat rash or sweat rash caused by blocked sweat glands

Warnings & Precautions

Who should not use flurandrenolide?

Allergies to Ingredients. People who are allergic to any of the following should not use flurandrenolide.

  • Flurandrenolide
  • Cordran
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in the specific flurandrenolide products they stock.

What should I know about flurandrenolide before using it?

Do not use flurandrenolide unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share flurandrenolide with other people, even if they have the same condition as you. It may harm them.

Keep flurandrenolide out of the reach of children.

Flurandrenolide is for use on the skin only. Keep flurandrenolide away from your eyes.

Avoid using flurandrenolide topical lotion, cream, or ointment on your face, groin, or armpits, unless your health care provider instructed you to do so.

Avoid using flurandrenolide topical tape on skin areas that are oozing or on areas where your skin can rub together.

Do not bandage, wrap, or otherwise seal the area where flurandrenolide is applied, unless your health care provider instructed you to do so. This includes applying flurandrenolide to the diaper area (diapers or plastic pants may seal the area).

Flurandrenolide topical tape should always be cut, never torn. If the ends of flurandrenolide topical tape becomes loose before it is time to remove it, you may trim off the tape and replace it with fresh tape.

Stop using flurandrenolide topical lotion, cream, or ointment once your skin condition is under control. If no improvement in your skin is seen within two weeks, tell your health care provider right away.

Flurandrenolide, when used on children, may slow the height and weight growth. The risk may be higher in those who use it for an extended period of time. Tell your child’s health care provider if you have concerns about their growth.

What should I tell my health care provider before using flurandrenolide?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if flurandrenolide is right for you.

In particular, make sure that you discuss any of the following.

Other Medicines and Supplements. Flurandrenolide may interact with other medicines and supplements. Before using flurandrenolide, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Adrenal Gland Problems. Flurandrenolide can cause reduced adrenal function. See the Side Effects section for more details. Tell your health care provider if you have any adrenal gland problems.

Diabetes. Flurandrenolide can increase your blood sugar. See the Side Effects section for more details. Tell your health care provider if you have diabetes.

Skin Infections. Tell your health care provider if you currently have a skin infection. The infection may need to be treated first before you should use flurandrenolide.

Pregnancy. It is not known if or how flurandrenolide could affect pregnancy or harm an unborn baby. Tell your health care provider if you are or plan to become pregnant.

Breastfeeding. It is not known if flurandrenolide passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will advise you if you should use flurandrenolide while breastfeeding.

Interactions

Does flurandrenolide interact with foods or drinks?

There are no known interactions between flurandrenolide and foods or drinks.

It is unknown if drinking alcohol will affect flurandrenolide.

Does flurandrenolide interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, skin products, and other supplements you are using.

In particular, make sure that you discuss if you are using or taking any other corticosteroid, including medicines you take by mouth as well as other medicines you apply to the skin. Examples include prednisone, dexamethasone, or methylprednisolone, which are medicines for certain inflammatory conditions.

This may not be a complete list of medicines that can interact with flurandrenolide. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much flurandrenolide?

If you or someone else has used too much flurandrenolide, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of flurandrenolide?

If you miss your scheduled dose of flurandrenolide, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and follow the original schedule. Do not apply flurandrenolide more often than prescribed.