Reviews Overview: Exdensur is used to help lower the number of asthma attacks in certain people with a severe form of asthma called eosinophilic asthma. This medicine is given to you by a health care provider as an injection under your skin every 6 months. Do not stop or change how you use other medicines for asthma unless directed by your health care provider. Sneezing, nasal congestion, runny nose, nasal itching, and sore throat are common side effects. Tell your health care provider if your breathing does not improve or worsens after starting this medicine.
Uses
What is Exdensur used for?
Exdensur (depemokimab-ulaa) is commonly used to help prevent asthma attacks in certain people with a severe type of asthma called eosinophilic asthma.
Managing Severe Eosinophilic Asthma With Exdensur
Exdensur may also be used for other conditions as determined by your health care provider.
How does Exdensur work (mechanism of action)?
In people with eosinophilic asthma, swelling (inflammation) in the lungs is caused by having too many eosinophils, which are a certain type of immune cell. A substance in the body, called interleukin-5 (IL-5), plays a key role in telling the body to make more eosinophils. Exdensur blocks IL-5, reducing the number of eosinophils and the amount of swelling in the lungs. This medicine helps to prevent asthma attacks.
How is Exdensur supplied (dosage forms)?
Exdensur is available in an injectable form that is given by a health care provider.
How should I store Exdensur?
Exdensur is usually given by a health care provider in a hospital or clinic. You will not store Exdensur at home.
Side Effects
What are the most common side effects of Exdensur?
The most common side effects of Exdensur are listed below. Tell your health care provider if you have any of these side effects that bother you.
- Infection in the nose or sinuses, sore throat, or common cold symptoms
- Influenza or flu-like symptoms
- Hay fever (sneezing, nasal congestion, runny nose, and nasal itching)
- Joint pain
There may be other side effects of Exdensur that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Exdensur?
While less common, the most serious side effects of Exdensur are described below, along with what to do if they happen.
Severe Allergic Reactions. Exdensur may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Warnings & Precautions
Who should not use Exdensur?
Allergies to Ingredients. People who are allergic to any of the following should not use Exdensur.
- Depemokimab-ulaa
- Exdensur
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Exdensur.
What should I know about Exdensur before using it?
Exdensur is usually given by a health care provider in a hospital or clinic.
Call your health care provider if your breathing does not get better or gets worse after starting Exdensur.
If you use other medicines for your asthma, talk with your healthcare provider about when and how to use each of them. Do not stop or change any medicines like a corticosteroid you use for asthma without first talking to your health care provider.
Exdensur is used on a regular schedule to prevent symptoms. Exdensur does not treat an asthma attack. Certain inhaled medicines, sometimes called rescue inhalers, should be used to treat sudden breathing problems. Get medical help right away if your breathing does not get better after using a rescue inhaler.
What should I tell my health care provider before using Exdensur?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Exdensur is right for you.
In particular, make sure that you discuss any of the following.
Parasitic Worm Infection. Tell your health care provider if you have or think you may have a worm (helminth) infection. Your health care provider may need to wait to start this medicine or stop it for a period of time depending on when you got the worm infection.
Corticosteroid Use. Tell your health care provider if you use a medicine called a corticosteroid. You may use an inhaled corticosteroid and/or one that you take by mouth. Your health care provider will tell you if you need to make any changes to your corticosteroid dose. Do not make any changes on your own, including stopping a corticosteroid. If a corticosteroid dose is lowered, you may have withdrawal symptoms or symptoms from a condition that had been hidden because of the corticosteroid. Any reductions in a corticosteroid dose needs to be supervised by your health care provider.
Pregnancy. It is not known if or how Exdensur could affect pregnancy or harm an unborn baby. Tell your health care provider right away if you are pregnant, think you may be pregnant, or plan to become pregnant. If you get pregnant while using Exdensur, you are encouraged to call the drugmaker at 888-825-5249 to report the exposure. Your baby could be exposed to increased levels of this medicine for a prolonged period of time.
Breastfeeding. It is not known if Exdensur passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Exdensur while breastfeeding.
How can I get more information about Exdensur?
For more information about Exdensur, you can visit the drugmaker’s website at www.exdensur.com or call them at 833-393-3678.
Interactions
Does Exdensur interact with foods or drinks?
There are no known interactions between Exdensur and foods or drinks.
There are no known interactions between Exdensur and alcohol.
Does Exdensur interact with other medicines (drug interactions)?
There are no known interactions between Exdensur and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
This may not be a complete list of medicines that can interact with Exdensur. Always check with your health care provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Exdensur?
If you or someone else has used too much Exdensur, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Exdensur?
Exdensur is usually given by a health care provider in a hospital. Your health care provider will make sure you are receiving Exdensur as scheduled.
If you miss an appointment to get your Exdensur dose, call to make another appointment as soon as possible.
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