6 mins read

Enspryng is used to treat neuromyelitis optica spectrum disorder (NMOSD) or thyroid eye disease (TED). Common side effects include infection of the nose or throat, headache, nausea, and joint pain. Keep all appointments to have your blood checked. Call your health care provider right away if you think you have an infection or get a fever, chills, cough, or sore throat. Enspryng is a liquid that is injected under the skin.

Uses

What is Enspryng used for?

Enspryng (satralizumab-mwge) is used to treat certain people with an autoimmune condition called neuromyelitis optica spectrum disorder (NMOSD), which affects your eyes and spinal cord.

Enspryng is also used to treat thyroid eye disease (TED), an autoimmune condition that affects the way your eyes look and work.

Learn more about Enspryng for neuromyelitis optica spectrum disorder.

Enspryng may also be used for other conditions as determined by your health care provider.

How does Enspryng work (mechanism of action)?

Neuromyelitis optica spectrum disorder (NMOSD) and thyroid eye disease (TED) are autoimmune conditions, meaning the immune system mistakenly attacks the body's own tissues. Enspryng blocks the receptor for interleukin-6 (IL-6), a chemical messenger involved in inflammation. It is thought that by blocking that signal, Enspryng helps reduce relapses in NMOSD and may help improve symptoms of TED, such as eye bulging.

How is Enspryng supplied (dosage forms)?

Brands and other names

  • Enspryng

Dosage forms and strengths

  • 120 mg/mL single-dose prefilled syringe
  • 120 mg/mL and 180 mg/1.5 mL single-dose prefilled autoinjector

How should I store Enspryng?

Store Enspryng in the original carton in the refrigerator, between 36 F and 46 F (2 C and 8 C). Unopened Enspryng can be removed from and returned to the refrigerator. The combined total time that unopened Enspryng can be stored out of the refrigerator is 8 days at temperatures that are no higher than 86 F (30 C). Protect from light and always keep it in the original carton. Do not freeze or shake. 

Side Effects

What are the most common side effects of Enspryng?

The most common side effects of Enspryng are listed below. These side effects may vary depending on the condition that is being treated. Tell your health care provider if you have any of these side effects that bother you.

  • Infections in the nose or throat, sore throat, or common cold symptoms (see below)
  • Headache
  • Inflammation of the stomach lining (gastritis)
  • Rash
  • Joint pain
  • Pain in your arms and legs
  • Tiredness
  • Nausea
  • Increased liver enzymes (see below)

There may be other side effects of Enspryng that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Enspryng?

While less common, the most serious side effects of Enspryng are described below, along with what to do if they happen.

Severe Allergic Reactions. Enspryng may cause allergic reactions, which can be serious. Stop using Enspryng and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infections. Enspryng can increase your risk of infections, including serious infections. Call your health care provider right away if you have an infection or any of the following symptoms.

  • Burning or stinging when you pee 
  • Cough or coughing up blood
  • Fever, sweats, chills, or muscle aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Weight loss

Increased Liver Enzymes. Enspryng can increase your liver enzymes. This medicine may need to be stopped if your liver enzymes get too high. Keep all appointments to have your blood checked. 

Low Neutrophil Levels (Neutropenia). Enspryng may cause low levels of a type of white blood cell (called neutrophils), which is known as neutropenia. Neutrophils help prevent infection. Having a low level of neutrophils may increase your risk of infection. Keep all appointments to have your blood checked. Tell your health care provider right away if you have any of the following symptoms of low neutrophil levels.

  • Fever, chills, or sweats
  • Tiredness
  • Sore throat, cough, or shortness of breath
  • Mouth or throat sores
  • Swollen lymph nodes

Warnings & Precautions

Who should not use Enspryng?

Allergies to Ingredients. People who are allergic to any of the following should not use Enspryng.

  • Enspryng
  • Satralizumab-mwge
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Enspryng.

Hepatitis B. Do not use Enspryng if you have an active hepatitis B infection.

Tuberculosis.Do not use Enspryng if you have tuberculosis (TB) or untreated latent TB. Latent TB is when you still have TB in your body, but the infection does not spread or cause any symptoms. 

What should I know about Enspryng before using it?

Do not use Enspryng unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Enspryng with other people, even if they have the same condition as you. It may harm them.

Keep Enspryng out of the reach of children. Since this medicine should be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.

This medicine is injected under the skin (subcutaneously) in your lower stomach area or the front/middle of your thighs. Make sure that you or a caregiver understands how to properly prepare and use Enspryng. If you have any questions, talk to your health care provider.

Keep all appointments with your health care provider, including for blood work, before starting and while using Enspryng. 

What should I tell my health care provider before using Enspryng?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Enspryng is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • An infection
  • History of hepatitis B
  • History of tuberculosis (TB) or been in contact with someone who has tuberculosis
  • Liver problems
  • Low neutrophil levels

Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines right before or while using Enspryng. Tell your health care provider about any vaccines you have recently received or have scheduled.

Pregnancy. It is not known if or how Enspryng could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should use Enspryng while you are pregnant or trying to get pregnant. If you become pregnant while using Enspryng and you have NMOSD, you can sign up for the Enspryng pregnancy registry by calling 833-277-9338. This registry collects safety information about the use of Enspryng during pregnancy in people with NMOSD.

Breastfeeding. It is not known if Enspryng passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Enspryng while breastfeeding.

How can I get more information about Enspryng?

For more information about Enspryng, you can visit the drugmaker’s website at www.enspryng.com or call them at 844-677-7964.

Interactions

Does Enspryng interact with foods or drinks?

There are no known interactions between Enspryng and foods or drinks.

There are no known interactions between Enspryng and alcohol.

Does Enspryng interact with other medicines (drug interactions)?

Enspryng may interact with certain medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Enspryng?

If you or someone else has used too much Enspryng, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Enspryng?

Try not to miss a dose of this medicine. Use a calendar or set a reminder on your phone to help you keep on schedule. Call your health care provider if you miss a dose of Enspryng. Do not use double or extra doses.