Overview: Ebglyss is a biologic treatment for moderate to severe eczema, also known as atopic dermatitis. It is given as an injection under your skin. It works by targeting a protein that contributes to ongoing inflammation. It may cause pain or irritation at the injection site. It may also cause eye problems, including redness or itching. Tell your health care provider right away if you have eye pain, swelling, or vision changes.
Uses
What is Ebglyss used for?
Ebglyss (lebrikizumab-lbkz) is commonly used to treat a skin condition that causes dry, itchy, inflamed skin called atopic dermatitis or eczema.
Ebglyss may also be used for other conditions as determined by your health care provider.
How does Ebglyss work (mechanism of action)?
Ebglyss works by blocking the effect of a substance called interleukin-13 (IL-13). This substance is normally made by your body and is part of your body’s response to inflammation. Blocking this substance can help treat the symptoms of atopic dermatitis.
Learn more about how Ebglyss works for eczema.
How is Ebglyss supplied (dosage forms)?
Brands and other names
Ebglyss
Dosage forms and strengths
- 250 mg/2 mL single-dose prefilled pen
- 250 mg/2 mL single-dose prefilled syringe
How should I store Ebglyss?
Store Ebglyss in the original carton in a refrigerator, between 36 F and 46 F (2 C and 8 C). Do not freeze Ebglyss. You can store Ebglyss for up to 7 days at room temperature, up to 86 F (30 C), in the original carton to protect it from light. Do not store Ebglyss above 86 F (30 C) or in direct sunlight. Throw Ebglyss away if it was heated, frozen, or after 7 days if kept at room temperature.
Side Effects
What are the most common side effects of Ebglyss?
The most common side effects of Ebglyss are listed below. Tell your health care provider if you have any of these side effects that bother you.
- Eye problems, such as eyelid redness, swelling, or itching, called conjunctivitis (see below)
- Pain, redness, itching, or swelling at the injection site
- Shingles (herpes zoster)
There may be other side effects of Ebglyss that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Ebglyss?
While less common, the most serious side effects of Ebglyss are described below, along with what to do if they happen.
Severe Allergic Reactions. Ebglyss may cause allergic reactions, which can be serious. Stop using Ebglyss and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Eye Problems. Ebglyss may cause eye problems, such as pink eye (conjunctivitis) and inflammation of the cornea (keratitis). Contact your health care provider right away if you have any of the following symptoms.
- Eye redness, itchiness, or pain
- Swollen or itchy eyelids
- Feeling like you have something in your eye
- Eye dryness, watering, or discharge
- Vision changes, such as blurry vision or sensitivity to light
Warnings & Precautions
Who should not use Ebglyss?
Allergies to Ingredients. People who are allergic to any of the following should not use Ebglyss.
- Ebglyss
- Lebrikizumab-lbkz
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Ebglyss.
What should I know about Ebglyss before using it?
Do not use Ebglyss unless it has been prescribed to you by a health care provider. Use it as prescribed.
Do not share Ebglyss with other people, even if they have the same condition as you. It may harm them.
Keep Ebglyss out of the reach of children. Since this medicine may be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.
This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Ebglyss. If you have any questions, ask your health care provider.
Look at the liquid in the pen chamber or syringe before using. Do not use Ebglyss if the liquid is cloudy or contains visible particles. The solution should be clear, colorless, slightly yellow, or slightly brown. Do not use Ebglyss if the pen or syringe is broken, damaged, or cracked.
Do not shake Ebglyss. This can damage the medicine.
Inject Ebglyss into your front upper thigh or abdomen. Avoid injecting too close to the belly button, knee, or groin. Ebglyss can also be injected into your upper arm but only if it is given by your health care provider or caregiver.
Use a different injection site each time you use Ebglyss. Do not give the injection into tender areas, bruises, scars, red skin, hard skin, or skin that is affected by eczema.
Throw away Ebglyss after you use a dose, even if there is medicine left in the pen or syringe. Each pen or syringe is good for just one use. Discard Ebglyss in a sharps container or in a household container made of heavy-duty plastic that is able to close tightly and is puncture- and leak-resistant.
What should I tell my health care provider before using Ebglyss?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Ebglyss is right for you.
In particular, make sure that you discuss any of the following.
Parasite Infection. Ebglyss might make it hard for your body to fight certain parasite infections caused by worms (helminths). Tell your health care provider if you have a worm infection so it can be treated before you start Ebglyss. If you become infected with a worm, such as pinworm, tell your health care provider.
Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines right before or while using Ebglyss. Tell your health care provider about any vaccines you have recently received or have scheduled.
Pregnancy. It is not known if or how Ebglyss could affect pregnancy or harm a fetus. Tell your health care provider if you are or plan to become pregnant. If you become pregnant while using Ebglyss, you or your health care provider can report it to the drugmaker by calling 800-545-5979. They will collect safety information about the use of Ebglyss during pregnancy.
Breastfeeding. It is not known if Ebglyss passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Ebglyss while breastfeeding.
How can I get more information about Ebglyss?
For more information about Ebglyss, you can visit the drugmaker's website at www.ebglyss.com or call them at 800-545-5979.
Interactions
Does Ebglyss interact with foods or drinks?
There are no known interactions between Ebglyss and foods or drinks.
It is unknown if drinking alcohol will affect Ebglyss.
Does Ebglyss interact with other medicines (drug interactions)?
There are no known interactions between Ebglyss and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
Overdose/Missed Dose
What should I do if I accidentally use too much Ebglyss?
If you or someone else has used too much Ebglyss, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Ebglyss?
If you miss a dose of Ebglyss, inject the dose as soon as you remember. Inject your next scheduled dose at your regular time.
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