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Overview: Durysta is used to lower high pressure inside the eye in people with open-angle glaucoma or ocular hypertension. It is an implant, given as an injection into the eye by a health care provider, that works by helping fluid drain out of the eye, which lowers the pressure. Common side effects include eye redness, a feeling like something is in the eye, eye pain or irritation, dry eyes, sensitivity to light, and blurry vision. Call your health care provider right away if you have trouble breathing, a racing heart, new vision changes, or if the colored part of your eye increases in brown color.

Uses

What is Durysta used for?

Durysta (bimatoprost) is commonly used to reduce increased pressure in the eye in people with either open-angle glaucoma or ocular hypertension.

Durysta may also be used for other conditions as determined by your health care provider.

How does Durysta work (mechanism of action)?

Durysta is part of a group of medicines called prostaglandin analogs. People with glaucoma or ocular hypertension have high intraocular pressure (IOP), or high pressure inside the eye, which increases the risk for vision loss and nerve damage in the eyes. Durysta is an implant that is injected into the eye by a health care provider. It works by helping the fluid in the eye drain out, which helps decrease IOP. 

How is Durysta supplied (dosage forms)?

Durysta is available as an implant that is inserted into the eye by a health care provider.

How should I store Durysta?

Durysta is given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Durysta?

The most common side effects of Durysta are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Eye redness
  • Feeling like something is in the eye
  • Eye pain or irritation
  • Dry eyes
  • Sensitivity to light
  • A red patch on the white part of the eye 
  • Blurry vision
  • Headache 
  • Inflammation of the iris, the colored part of the eye

There may be other side effects of Durysta that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Durysta?

While less common, the most serious side effects of Durysta are described below, along with what to do if they happen.

Severe Allergic Reactions. Durysta may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Increased Brown Coloring of the Iris. Durysta may cause the colored part of the eye called the iris to increase in brown color. This effect may take months to years to occur, and may be permanent. Keep all appointments to have your eyes checked.

Eye Inflammation and Macular Edema. Durysta may cause inflammation in your eye, including a problem called macular edema. Macular edema is swelling from too much fluid in part of your eye called the retina. This can affect your vision. If you have any vision changes, call your health care provider right away.

Warnings & Precautions

Who should not use Durysta?

Allergies to Ingredients. People who are allergic to any of the following should not use Durysta.

  • Bimatoprost
  • Durysta
  • Any of the ingredients in Durysta

Your health care provider can tell you all of the ingredients in Durysta.

Eye Infections. People with infections of the eye or around the eye should not receive Durysta.

Corneal Endothelial Cell Dystrophy. People with a condition called corneal endothelial cell dystrophy (Fuch’s dystrophy) should not use Durysta. Corneal endothelial cell dystrophy is a condition where the cells that keep the cornea (the clear front part of the eye) healthy start to break down, causing vision problems.

Previous Corneal Transplantation. People who have had a previous corneal transplantation, or endothelial cell transplants such as Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK), should not use Durysta.

Absent or Ruptured Posterior Lens Capsule. The posterior lens capsule is a layer of tissue that holds the lens in place and maintains its shape. People with a ruptured or absent posterior lens capsule should not use Durysta.

What should I know about Durysta before using it?

Do not lie down for at least an hour after you receive Durysta. The medicine needs to settle in the right place in your eye.

Your eye will likely be red and somewhat uncomfortable after you receive Durysta. However, if your eye becomes more red and uncomfortable or if you get eye pain, sensitivity to light, or vision changes, get medical help from your eye doctor right away.

What should I tell my health care provider before using Durysta?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Durysta is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Any type of eye problem, including uveitis (inflammatory conditions that affect the middle part of the eye), macular edema, narrow angles, obstruction (a blockage), eye pressure problems, no lens (aphakia), or problems with your eye lens
  • Diabetes 
  • A history of eye surgery

Pregnancy. It is not known if or how Durysta could affect pregnancy or harm a fetus. Tell your health care provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Durysta passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Durysta while breastfeeding.

How can I get more information about Durysta?

For more information about Durysta, you can visit the drugmaker's website at www.durysta.com or call them at 833-DURYSTA (833-387-9782).

Interactions

Does Durysta interact with foods or drinks?

There are no known interactions between Durysta and foods or drinks.

It is unknown if drinking alcohol will affect Durysta.

Does Durysta interact with other medicines (drug interactions)?

There are no known interactions between Durysta and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. 

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Durysta?

Durysta is an implant that is inserted into the eye by a health care provider. You cannot use too much.

What should I do if I miss a dose of Durysta?

Durysta is an implant that is inserted into the eye by a health care provider. If you already received Durysta, you will not get another in the same eye.