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Overview: Adquey is an ointment that you apply to the skin to treat a common type of eczema. It works by calming inflammation. The most common side effects are common cold symptoms, such as sore throat or runny nose. Stop using Adquey and contact your health care provider right away if you have severe skin irritation or blistering. Do not use Adquey on any areas of the skin that are infected.

Uses

What is Adquey used for?

Adquey (difamilast) is commonly used to treat a skin condition called atopic dermatitis. It is a type of eczema that causes itchiness, rashes, and dry, scaly skin.

What to Know About Adquey for Atopic Dermatitis

Adquey may also be used for other conditions as determined by your health care provider.

How does Adquey work (mechanism of action)?

Adquey works by blocking a protein in the body called phosphodiesterase-4 (PDE4), which is thought to help calm inflammation.

How is Adquey supplied (dosage forms)?

Adquey is available as a 1% topical ointment that is applied to the skin.

How should I store Adquey?

Adquey should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place that is away from direct sunlight. Keep the tube tightly closed between uses.

Side Effects

What are the most common side effects of Adquey?

The most common side effects of Adquey are listed below. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of Adquey that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Adquey?

While less common, the most serious side effects of Adquey are described below, along with what to do if they happen.

Severe Allergic Reactions. Adquey may cause allergic reactions, which can be serious. Stop using Adquey and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Skin pain, burning sensation, irritation, or blistering
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Adquey?

Allergies to Ingredients. People who are allergic to any of the following should not use Adquey.

  • Adquey
  • Difamilast
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Adquey.

What should I know about Adquey before using it?

Do not use Adquey unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Adquey with other people, even if they have the same condition as you. It may harm them.

Keep Adquey out of the reach of children.

Adquey is for use on the skin only. It should not be used on other areas of the body such as the eyes, mouth, or vagina. Do not use Adquey on areas of the skin that are infected. 

Apply a thin layer of Adquey to affected areas and rub it in completely. Wash your hands after use.

What should I tell my health care provider before using Adquey?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Adquey is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Adquey could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Adquey passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Adquey while breastfeeding. If you use Adquey while breastfeeding, do not apply it to the nipple area to avoid getting the medicine in your baby’s mouth. If you apply Adquey to the chest area, make sure the treated skin does not directly touch your baby’s skin.

How can I get more information about Adquey?

For more information about Adquey, you can visit the drugmaker’s website at www.Adquey.com or call them at 866-850-2876.

Interactions

Does Adquey interact with foods or drinks?

There are no known interactions between Adquey and foods or drinks.

It is unknown if drinking alcohol will affect Adquey.

Does Adquey interact with other medicines (drug interactions)?

There are no known interactions between Adquey and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Adquey?

If you or someone else has used too much Adquey, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Adquey?

If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses.