5 mins read

Overview: Adbry is used to treat moderate to severe eczema in people whose topical treatments have not worked well enough or cannot be used. It works by blocking a protein that triggers the inflammation behind eczema symptoms like skin lesions and itchiness. Common side effects include infection in the nose or throat, itchy or red eyes, and pain, itching, swelling, or redness near the injection site. Call your health care provider right away if you have breathing problems, eye redness, pain, or vision changes.

Uses

What is Adbry used for?

Adbry (tralokinumab) is commonly used to treat a skin condition called atopic dermatitis (eczema). Adbry may be used if your eczema is moderate to severe and topical treatments that you apply to the skin have not helped enough or cannot be used.

Adbry for Atopic Dermatitis: What You Need to Know

Adbry may also be used for other conditions as determined by your health care provider.

How does Adbry work (mechanism of action)?

Skin lesions, itchiness, and other symptoms of atopic dermatitis (eczema) are caused in part by inflammation. Adbry works by blocking a protein that triggers inflammation.

How is Adbry supplied (dosage forms)?

Brands and other names

  • Adbry

Dosage forms and strengths

  • 150 mg/mL solution for injection, prefilled syringe
  • 300 mg/2 mL solution for injection, autoinjector

How should I store Adbry?

Store Adbry in the refrigerator, between 36 F and 46 F (2 C and 8 C). 

You may store Adbry at room temperature, up to 86 F (30 C), for a maximum of 14 days. Do not place Adbry back in the refrigerator after it has been left out at room temperature. Dispose of any unused Adbry if it is kept at room temperature for longer than 14 days. See the Warnings & Precautions section for information about disposing of Adbry. 

Store Adbry in the original carton to protect it from light. Do not freeze, shake, or place it in direct sunlight.

Side Effects

What are the most common side effects of Adbry?

The most common side effects of Adbry are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Infection in the nose or throat, or common cold symptoms
  • Itchy, inflamed, or red eyes (see below)
  • Pain, itching, swelling, or redness near the injection site
  • High eosinophil count (a type of white blood cell)

There may be other side effects of Adbry that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Adbry?

While less common, the most serious side effects of Adbry are described below, along with what to do if they happen.

Severe Allergic Reactions. Adbry may cause allergic reactions, which can be serious. Stop using Adbry and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Severe Eye Problems. Adbry may cause eye problems, such as pink eye (conjunctivitis) and inflammation of the cornea (keratitis). Contact your health care provider right away if you have any of the following symptoms.

  • Eye redness, itchiness, or pain
  • Swollen or itchy eyelids 
  • Feeling like you have something in your eye
  • Eye dryness, watering, or discharge
  • Vision changes, such as blurry vision or sensitivity to light

Warnings & Precautions

Who should not use Adbry?

Allergies to Ingredients. People who are allergic to any of the following should not use Adbry.

  • Adbry
  • Tralokinumab-ldrm
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Adbry.

What should I know about Adbry before using it?

Do not use Adbry unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Adbry with other people, even if they have the same condition as you. It may harm them.

Keep Adbry out of the reach of children. Since this medicine may be stored in a refrigerator, take special care to keep it away from children who also use the refrigerator.

This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Adbry. If you have any questions, talk to your health care provider.

Adbry should be disposed of in a sharps container to protect others from contact with the attached needle. A health care professional can let you know how to dispose of Adbry safely. 

What should I tell my health care provider before using Adbry?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Adbry is right for you.

In particular, make sure that you discuss any of the following.

Parasite Infection. Adbry may make it harder for your body to fight certain parasite infections caused by worms (helminths). Tell your health care provider if you have a worm infection so it can be treated before you start Adbry. If you become infected with a worm, such as pinworm, tell your health care provider. They may stop your Adbry treatment until after the worm infection is treated.

Other Current and Past Health Conditions. Tell your health care provider if you have any eye problems.

Vaccines. Receiving a live vaccine while using Adbry may raise your risk of infection. Tell your health care provider about any vaccines you recently received or if you have any vaccines scheduled. They will let you know if you should wait to start your Adbry treatment until after you get any necessary vaccines.

Pregnancy. It is not known if or how Adbry could affect pregnancy or harm a fetus. Tell your health care provider if you are or plan to become pregnant. They will let you know if you should use Adbry while you are pregnant or trying to get pregnant. If you become pregnant while using this medicine, you can register for the Adbry Pregnancy Registry by calling 877-311-8972 or visiting mothertobaby.org/ongoing-study/adbry-tralokinumab. This registry collects safety information about using Adbry during pregnancy.

Breastfeeding. It is not known if Adbry passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Adbry while breastfeeding.

How can I get more information about Adbry?

For more information about Adbry, you can visit the drugmaker's website at www.adbry.com or call them at 877-494-4536.

Interactions

Does Adbry interact with foods or drinks?

There are no known interactions between Adbry and foods or drinks.

It is unknown if drinking alcohol will affect Adbry.

Does Adbry interact with other medicines (drug interactions)?

There are no known interactions between Adbry and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Adbry?

If you or someone else has used too much Adbry, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Adbry?

If you miss a dose, use it as soon as possible. Then continue Adbry at your usual dose at the next regular time.