Bysanti (milsaperidone) is used to treat certain mental health conditions. While Bysanti can be an effective treatment, it can interact with other medicines and substances.
A drug interaction happens when a medicine or substance affects how another medicine works in the body. Some medicines do not mix well because they have similar side effects, and taking them together can make those effects stronger.
This article does not include all possible Bysanti interactions. Communicating with your health care team can help you avoid unsafe combinations and ensure that your medicine works the way it should. Tell your health care provider and pharmacist about all prescription and over-the-counter medicines, vitamins, and supplements you take.
Understanding Bysanti Interactions
After you take Bysanti, your body breaks it down using certain enzymes mainly found in the liver and gut. Some medicines affect how these enzymes work. Medicines that block or slow (inhibit) them can raise Bysanti levels in your body, which increases the chance of side effects.
Below are more details about several Bysanti interactions.
1. Alpha-blockers
Also called alpha-adrenergic blockers, alpha-blockers are medicines commonly used to treat high blood pressure or symptoms of an enlarged prostate. Taking Bysanti with an alpha-blocker medicine may increase certain side effects of Bysanti.
Examples of alpha-blockers include:
- Alfuzosin
- Doxazosin
- Prazosin
- Silodosin
- Tamsulosin
- Terazosin
These medicines lower blood pressure by relaxing blood vessels. Bysanti can also affect blood pressure, especially when standing up. If taken together, the combined effects could cause blood pressure to drop too much. This can cause dizziness, lightheadedness, or fainting.
These medicines are usually not taken together. When taking Bysanti, your health care provider will likely recommend a different medicine instead of an alpha-blocker.
2. Other blood pressure medicines
Medicines that lower blood pressure may interact with Bysanti. The combination may increase certain side effects of Bysanti.
Some examples of blood pressure medicines include:
- An angiotensin-converting enzyme (ACE) inhibitor, such as enalapril or lisinopril
- An angiotensin II receptor blocker (ARB), such as losartan or valsartan
- A beta-blocker, such as atenolol, metoprolol, or propranolol
- A calcium channel blocker, such as amlodipine
- A diuretic (water pill), such as hydrochlorothiazide
These medicines help lower blood pressure. And so can Bysanti. If taken together, the combined effects could cause blood pressure to drop too low. This can lead to dizziness, lightheadedness, or fainting.
If you need to take both Bysanti and blood pressure medicine, your health care provider may monitor your blood pressure closely. They may need to adjust the dose of your blood pressure medicine. Do not change your dose on your own.
3. Certain antibiotics or antifungals
Some medicines for bacterial or fungal infections may interact with Bysanti. The combination may increase the risk of Bysanti side effects.
Examples include:
- Clarithromycin
- Itraconazole
- Ketoconazole
- Posaconazole
- Terbinafine
- Voriconazole
These medicines block certain enzymes in the body called cytochrome P450 (CYP) enzymes. Specifically, they block CYP3A4 or CYP2D6. When one (or both) of these enzymes is blocked, the body may break down Bysanti more slowly. This can increase the levels of Bysanti in the blood and raise the risk of side effects.
If you must take certain antibiotics or antifungal medicines while taking Bysanti, your health care provider may lower your Bysanti dose and monitor you for side effects.
4. Some antidepressants
Certain medicines that are used for depression or anxiety may interact with Bysanti and increase the risk of side effects.
Examples include:
These medicines can block the CYP2D6 enzyme. When this enzyme is blocked, the body may break down Bysanti more slowly. This can increase the levels of Bysanti in your body, raising the risk of side effects.
If you must take these medicines together, your health care provider may adjust your Bysanti dosage and monitor you more closely.
5. Certain antiviral or HIV medicines
Some medicines for treating viral infections or HIV may interact with Bysanti. The combination may increase the risk of side effects.
Examples include:
- Atazanavir
- Nirmatrelvir/ritonavir
- Ritonavir
- Tipranavir
These medicines can block CYP enzymes that help break down Bysanti in the body. When this happens, Bysanti levels may build up in the body, raising the risk or severity of side effects.
If both medicines are needed, your health care provider may reduce the dose of Bysanti and monitor you more closely.
6. Some medicines that affect your heart rhythm
Some medicines that affect the heart’s electrical rhythm may interact with Bysanti.
Some people taking Bysanti have had QT interval prolongation, which is a change in the heart’s electrical activity. This can increase the risk of abnormal heart rhythms. The risk may be higher if Bysanti is taken with other medicines that also prolong the QT interval.
Examples include:
- Amiodarone
- Chlorpromazine
- Methadone
- Moxifloxacin
- Procainamide
- Quinidine
- Sotalol
- Thioridazine
These medicines are usually not taken together with Bysanti because the combination may increase the risk of serious heart rhythm problems. Your health care provider may recommend a safer alternative.
Bysanti and Alcohol
Do not drink alcohol while taking Bysanti.
Combining alcohol and Bysanti may increase the risk of side effects, such as drowsiness and dizziness. Alcohol can also worsen some symptoms of mental health conditions.
How to Avoid Bysanti Interactions
Bysanti may interact with medicines, supplements, or herbal products not listed in this article. Many substances can change how medicines are processed in the body, which may affect how well Bysanti works or increase the risk of side effects.
One of the best ways to prevent interactions is to keep your health care team informed about everything you take. Your prescriber and pharmacist can review your medicine list and check for possible interactions before problems occur.
To reduce the risk of Bysanti interactions, make sure to:
- Take Bysanti exactly as prescribed.
- Keep an up-to-date list of all medicines and supplements, including prescription medicines, over-the-counter products, vitamins, and herbal supplements.
- Share this list with all your health care providers and any pharmacy you use, especially before you start Bysanti or when any medicine changes.
- Dispose of unused or expired medicines properly to prevent accidental use.
Your health care provider and pharmacist can check your medicines for interactions and help make sure your treatment plan is safe for you.
